Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 17/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.44 |
| ▸ | CTRC | Q99895 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5674410 | 0.90 | F2 (0.59) | F2PRSS2CTRC | |
| SCHEMBL5674416 | 0.89 | F2 (0.56) | F2PRSS2CTRC | |
| SCHEMBL5672970 | 0.87 | F2 (0.54) | F2PRSS2CTRC | |
| SCHEMBL5673538 | 0.86 | F2 (0.53) | F2GLASMN1; SMN2CTRCTSHR | |
| SCHEMBL5676136 | 0.85 | F2 (0.72) | F2PRSS2CTRC | |
| SCHEMBL5672814 | 0.82 | SMN1; SMN2 (0.49) | F2GLASMN1; SMN2TSHRPKM | |
| SCHEMBL5673429 | 0.82 | F2 (0.70) | F2PRSS2CTRC | |
| SCHEMBL5673614 | 0.79 | F2 (0.70) | F2PRSS2CTRC | |
| SCHEMBL8480689 | 0.79 | SMN1; SMN2 (0.47) | F2GLASMN1; SMN2TSHRPKM | |
| SCHEMBL5674472 | 0.78 | F2 (0.55) | F2PRSS2CTRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906091-B1 | AMIDINOHYDRAZONES AS PROTEASE INHIBITORS | ORTHO MCNEIL PHARM INC (US) | 2006-10-04 | — | — | EP | disclosed |
| EP-0906091-A4 | AMIDINOHYDRAZONES AS PROTEASE INHIBITORS | DIMENSIONAL PHARM INC (US) | 2004-07-21 | — | — | EP | disclosed |
| EP-0906091-A1 | AMIDINOHYDRAZONES AS PROTEASE INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 1999-04-07 | — | — | EP | disclosed |
| US-5891909-A | Amidinohydrazones as protease inhibitors | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 1999-04-06 | — | — | US | disclosed |
| WO-1997036580-A1 | AMIDINOHYDRAZONES AS PROTEASE INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 1997-10-09 | — | — | WO | disclosed |