Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.52 |
| ▸ | MEN1 | O00255 | 8/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.52 |
| ▸ | NPC1 | O15118 | 6/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | PDE3B | Q13370 | 7/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.51 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.51 |
| ▸ | GALR3 | O60755 | 3/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | GAA | P10253 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.48 |
| ▸ | CCR6 | P51684 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 4/20 | 0.47 |
| ▸ | XBP1 | P17861 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5677353 | 1.00 | MAPT (0.52) | MAPTMEN1KMT2ANPC1MAPK1 | |
| SCHEMBL5678906 | 0.88 | MAPT (0.55) | MAPTKMT2AMAPK1PDE3BPDE3A | |
| SCHEMBL5678902 | 0.88 | MAPT (0.55) | MAPTKMT2AMAPK1PDE3BPDE3A | |
| SCHEMBL27494992 | 0.88 | MAPT (0.52) | MAPTMEN1KMT2ANPC1MAPK1 | |
| SCHEMBL5678987 | 0.87 | PDE3B (0.56) | MAPTMAPK1PDE3BPDE3ATNNC1 | |
| SCHEMBL5678983 | 0.87 | PDE3B (0.56) | MAPTMAPK1PDE3BPDE3ATNNC1 | |
| SCHEMBL5679134 | 0.86 | PDE3B (0.52) | MAPTMEN1KMT2AMAPK1POLB | |
| SCHEMBL5679128 | 0.86 | PDE3B (0.52) | MAPTMEN1KMT2AMAPK1POLB | |
| SCHEMBL5680478 | 0.85 | PDE3B (0.54) | MAPTMEN1KMT2ANPC1MAPK1 | |
| SCHEMBL5680473 | 0.85 | PDE3B (0.54) | MAPTMEN1KMT2ANPC1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1265871-B1 | PYRIDAZINYL PHENYL HYDRAZONES USEFUL AGAINST CONGESTIVE HEART FAILURE | ORION CORP (FI) | 2006-02-08 | — | — | EP | disclosed |
| US-6699868-B2 | INCREASE THE CALCIUM SENSITIVITY OF CONTRACTILE PROTEINS OF THE CARDIAC MUSCLE | ORION CORPORATION (FI) | 2004-03-02 | — | — | US | disclosed |
| US-20030158200-A1 | Pyridazinyl phenyl hydrazones useful against congestive heart failure | ORION CORPORATION (FI) | 2003-08-21 | — | — | US | disclosed |
| EP-1265871-A1 | PYRIDAZINYL PHENYL HYDRAZONES USEFUL AGAINST CONGESTIVE HEART FAILURE | ORION CORPORATION (FI) | 2002-12-18 | — | — | EP | disclosed |
| WO-2001068611-A1 | PYRIDAZINYL PHENYL HYDRAZONES USEFUL AGAINST CONGESTIVE HEART FAILURE | ORION CORPORATION (FI) | 2001-09-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030158200-A1 | Pyridazinyl phenyl hydrazones useful against congestive heart failure | FABP3, TNNI3, TNNT2 | MAPT 4871/4885MEN1 4874/4885KMT2A 4528/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.