Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STS | P08842 | 7/20 | 0.70 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.70 |
| ▸ | HSD17B1 | P14061 | 6/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | MAPT | P10636 | 2/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.70 |
| ▸ | ESR1 | P03372 | 2/20 | 0.70 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.70 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.70 |
| ▸ | SHBG | P04278 | 1/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.70 |
| ▸ | PGR | P06401 | 1/20 | 0.70 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.70 |
| ▸ | AR | P10275 | 1/20 | 0.70 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.70 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.70 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.70 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.70 |
| ▸ | SNCA | P37840 | 1/20 | 0.70 |
| ▸ | HTR2B | P41595 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14079692 | 1.00 | STS (0.70) | STSCYP19A1HSD17B1LMNAMAPT | |
| SCHEMBL10031984 | 1.00 | STS (0.70) | STSCYP19A1HSD17B1LMNAMAPT | |
| SCHEMBL29539187 | 1.00 | STS (0.70) | STSCYP19A1HSD17B1LMNAMAPT | |
| SCHEMBL1258196 | 1.00 | STS (0.70) | STSCYP19A1HSD17B1LMNAMAPT | |
| SCHEMBL30958754 | 0.99 | STS (0.69) | STSCYP19A1HSD17B1LMNAMAPT | |
| Sulfuric Acid SCHEMBL29798778 | 0.94 | STS (0.67) | STSCYP19A1HSD17B1LMNAMAPT | |
| Piperazine SCHEMBL2818721 | 0.94 | CYP3A4 (0.64) | STSCYP19A1HSD17B1LMNAMAPT | |
| Sulfuric Acid SCHEMBL28338435 | 0.94 | STS (0.67) | STSCYP19A1HSD17B1LMNAMAPT | |
| SCHEMBL14513802 | 0.92 | HSD17B1 (0.72) | STSCYP19A1HSD17B1LMNAMAPT | |
| SCHEMBL17499964 | 0.89 | STS (0.57) | STSCYP19A1HSD17B1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060270845-A1 | 16-Hydroxyestratrienes as selectively active estrogens | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2006-11-30 | — | — | US | disclosed |
| US-7109360-B1 | 16-hydroxyestratrienes as selectively active estrogens | SCHERING AG (DE) | 2006-09-19 | — | — | US | disclosed |
| EP-1144431-B1 | 16-HYDROXYESTRATRIENES AS SELECTIVE ESTROGENS | SCHERING AG (DE) | 2005-12-21 | — | — | EP | disclosed |
| EP-1580192-A2 | 16-Hydroxyestratrienes as selective estrogens | Schering AG (DE) | 2005-09-28 | — | — | EP | disclosed |
| EP-1144431-A3 | 16-HYDROXYESTRATRIENES AS SELECTIVE ESTROGENS | Schering Aktiengesellschaft (DE) | 2002-06-12 | — | — | EP | disclosed |
| EP-1144431-A2 | 16-HYDROXYESTRATRIENES AS SELECTIVE ESTROGENS | Schering Aktiengesellschaft (DE) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000047603-A9 | 16-HYDROXYESTRATRIENES AS SELECTIVE ESTROGENS | SCHERING AG (DE) | 2001-09-07 | — | — | WO | disclosed |
| WO-2000047603-A2 | 16-HYDROXYESTRATRIENES AS SELECTIVE ESTROGENS | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-08-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060270845-A1 | 16-Hydroxyestratrienes as selectively active estrogens | ESR1, ESR2, ESRRA | STS 293/4885CYP19A1 10/4885HSD17B1 19/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.