Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 2/20 | 0.64 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.52 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.52 |
| ▸ | CCR2 | P41597 | 10/20 | 0.51 |
| ▸ | F10 | P00742 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7007261 | 0.98 | ABCB11 (0.62) | ABCB11NOD2NOD1CCR2F10 | |
| SCHEMBL6599360 | 0.91 | ABCB11 (0.77) | ABCB11NOD2NOD1CCR2F10 | |
| SCHEMBL6780026 | 0.89 | ABCB11 (0.64) | ABCB11NOD2NOD1CCR2F10 | |
| SCHEMBL6780426 | 0.88 | ABCB11 (0.62) | ABCB11NOD2NOD1CCR2F10 | |
| SCHEMBL5679412 | 0.88 | ABCB11 (0.63) | ABCB11NOD2NOD1CCR2F10 | |
| SCHEMBL6775631 | 0.86 | ABCB11 (0.64) | ABCB11NOD2NOD1CCR2F10 | |
| SCHEMBL7083815 | 0.86 | ABCB11 (0.61) | ABCB11NOD2NOD1CCR2F10 | |
| SCHEMBL7098037 | 0.84 | ABCB11 (0.59) | ABCB11NOD2NOD1CCR2F10 | |
| SCHEMBL6782501 | 0.84 | ABCB11 (0.58) | ABCB11NOD2NOD1CCR2F10 | |
| SCHEMBL7084148 | 0.84 | ABCB11 (0.61) | ABCB11NOD2NOD1CCR2F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268423-B1 | INDOLE DERIVATIVES AS MCP-1 RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2006-03-01 | — | — | EP | disclosed |
| US-6984657-B1 | Indole derivatives as MCP-1 receptor antagonists | ASTRAZENECA AB (SE) | 2006-01-10 | — | — | US | disclosed |
| EP-1268423-A1 | INDOLE DERIVATIVES AS MCP-1 RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001051467-A1 | INDOLE DERIVATIVES AS MCP-1 RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2001-07-19 | — | — | WO | disclosed |