Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | HPGD | P15428 | 2/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.68 |
| ▸ | MAPT | P10636 | 1/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | TOP2A | P11388 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.52 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5679660 | 0.93 | KDM4E (0.71) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL5681760 | 0.87 | KDM4E (0.71) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL5680865 | 0.85 | KDM4E (0.47) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL2157933 | 0.83 | KDM4E (0.85) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL5007407 | 0.83 | KDM4E (0.73) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL17350870 | 0.82 | KDM4E (0.82) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| Enrofloxacin SCHEMBL28556438 | 0.82 | KDM4E (0.93) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| Enrofloxacin SCHEMBL17554684 | 0.81 | KDM4E (1.00) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| Enrofloxacin SCHEMBL149150 | 0.81 | KDM4E (1.00) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| Enrofloxacin SCHEMBL29349852 | 0.81 | KDM4E (1.00) | KDM4EALDH1A1LMNAHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0831869-B1 | DIPHOSPHONATE DERIVATIVES OF THERAPEUTIC AGENTS | ELIZANOR BIOPHARMACEUTICALS IN (US) | 2006-02-08 | — | — | EP | disclosed |
| EP-0831869-A4 | DIPHOSPHONATE DERIVATIVES OF THERAPEUTIC AGENTS | ELIZANOR BIOPHARMACEUTICALS IN (US) | 1999-04-21 | — | — | EP | disclosed |
| EP-0831869-A1 | DIPHOSPHONATE DERIVATIVES OF THERAPEUTIC AGENTS | Elizanor Biopharmaceuticals, Inc. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996040190-A1 | DIPHOSPHONATE DERIVATIVES OF THERAPEUTIC AGENTS | ELIZANOR BIOPHARMACEUTICALS, INC. (US) | 1996-12-19 | — | — | WO | disclosed |