Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VDR | P11473 | 8/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6092884 | 1.00 | VDR (0.48) | VDRHDAC3HDAC6HDAC2 | |
| SCHEMBL5681021 | 0.94 | VDR (0.48) | VDRHDAC3HDAC6HDAC2 | |
| SCHEMBL5685271 | 0.90 | VDR (0.53) | VDR | |
| SCHEMBL7570782 | 0.90 | VDR (0.53) | VDR | |
| SCHEMBL5685297 | 0.90 | VDR (0.53) | VDR | |
| SCHEMBL5682392 | 0.90 | VDR (0.47) | VDR | |
| SCHEMBL5681036 | 0.90 | VDR (0.47) | VDR | |
| SCHEMBL5685110 | 0.89 | VDR (0.48) | VDRHDAC3HDAC6HDAC2 | |
| SCHEMBL5681016 | 0.89 | VDR (0.48) | VDRHDAC3HDAC6HDAC2 | |
| SCHEMBL6093885 | 0.88 | VDR (0.50) | VDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115758-B2 | Vitamin D derivatives with cyclic substructures in the side chains, process and intermediate products for their production, and the use for the production of pharmaceutical agents | SCHERING AG (DE) | 2006-10-03 | — | — | US | disclosed |
| EP-1210327-B1 | NEW VITAMIN D DERIVATIVES WITH CYCLIC SUBSTRUCTURES IN THE SIDE CHAINS, METHOD AND INTERMEDIATES FOR THEIR PRODUCTION AND THEIR USE IN THE PREPARATION OF MEDICAMENTS | SCHERING AG (DE) | 2006-01-18 | — | — | EP | disclosed |
| EP-1362848-A1 | Process for the preparation of vitamin D derivatives | Schering Aktiengesellschaft (DE) | 2003-11-19 | — | — | EP | disclosed |
| US-6603031-B1 | Active metabolites of vitamin D2 and vitamin D3 and their synthetic derivatives have a proliferation- inhibiting and differentiation-stimulating action on tumor cells and normal cells, | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-08-05 | — | — | US | disclosed |