Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.73 |
| ▸ | RAB9A | P51151 | 8/20 | 0.71 |
| ▸ | NPC1 | O15118 | 7/20 | 0.71 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | MLYCD | O95822 | 1/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27691100 | 0.88 | NPC1 (0.72) | SMN1; SMN2RAB9ANPC1HSP90AA1HDAC2 | |
| SCHEMBL25970084 | 0.87 | SMN1; SMN2 (0.96) | SMN1; SMN2RAB9ANPC1HPGDHDAC2 | |
| SCHEMBL20734830 | 0.85 | SMN1; SMN2 (1.00) | SMN1; SMN2RAB9ANPC1HPGDHDAC2 | |
| SCHEMBL3225126 | 0.84 | NPC1 (1.00) | SMN1; SMN2RAB9ANPC1HSP90AA1HPGD | |
| SCHEMBL9348556 | 0.83 | SMN1; SMN2 (0.76) | SMN1; SMN2RAB9ANPC1HPGDMEN1 | |
| SCHEMBL1577945 | 0.83 | SMN1; SMN2 (0.75) | SMN1; SMN2RAB9ANPC1HPGDMEN1 | |
| SCHEMBL11176654 | 0.82 | NPC1 (0.90) | SMN1; SMN2RAB9ANPC1HSP90AA1HPGD | |
| SCHEMBL25863565 | 0.82 | SMN1; SMN2 (0.74) | SMN1; SMN2RAB9ANPC1HPGDHDAC2 | |
| SCHEMBL1959872 | 0.82 | SMN1; SMN2 (0.73) | SMN1; SMN2RAB9ANPC1HPGDMEN1 | |
| SCHEMBL8115111 | 0.81 | NPC1 (0.87) | SMN1; SMN2RAB9ANPC1HSP90AA1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633714-A1 | 2-AMINO-PYRIDINE DERIVATIVES AS BETA-2 ADRENORECEPTOR AGONISTS | Pfizer Limited (GB) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004108675-A1 | 2-AMINO-PYRIDINE DERIVATIVES AS BETA-2 ADRENORECEPTOR AGONISTS | PFIZER LIMITED (GB) | 2004-12-16 | — | — | WO | disclosed |