Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 11/20 | 0.53 |
| ▸ | JAK3 | P52333 | 2/20 | 0.53 |
| ▸ | BTK | Q06187 | 2/20 | 0.53 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.53 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 12/20 | 0.47 |
| ▸ | SRC | P12931 | 9/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | TEK | Q02763 | 1/20 | 0.46 |
| ▸ | ULK1 | O75385 | 2/20 | 0.45 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.45 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.45 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 3/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4503811 | 0.96 | LCK (0.59) | LCKJAK3BTKTNK2TBK1 | |
| SCHEMBL4506463 | 0.96 | LCK (0.52) | LCKJAK3BTKTNK2TBK1 | |
| SCHEMBL4495966 | 0.93 | LCK (0.59) | LCKJAK3BTKTNK2TBK1 | |
| SCHEMBL4499811 | 0.92 | LCK (0.49) | LCKJAK3BTKTNK2TBK1 | |
| SCHEMBL4485430 | 0.92 | LCK (0.54) | LCKJAK3BTKTNK2TBK1 | |
| SCHEMBL4497970 | 0.91 | LCK (0.46) | LCKJAK3BTKTNK2TBK1 | |
| SCHEMBL4508592 | 0.90 | LCK (0.56) | LCKJAK3BTKTNK2KDR | |
| SCHEMBL5686155 | 0.89 | PTK2 (0.46) | LCKJAK3BTKTNK2TBK1 | |
| SCHEMBL4504900 | 0.89 | TBK1 (0.48) | LCKJAK3BTKTNK2TBK1 | |
| SCHEMBL4489145 | 0.88 | LCK (0.61) | LCKJAK3BTKTNK2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648464-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINCARBOXAMID DERIVATIVES AND RELATED COMPOUNDS AS T-CELL ACTIVATION INHIBITORS FOR THE TREATMENT OF INFLAMMATIONS | AMGEN INC. (US) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005009443-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF T CELL ACTIVATION FOR THE TREATMENT OF INFLAMMATORY DISEASES | AMGEN INC. (US) | 2005-02-03 | — | — | WO | disclosed |