Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 8/20 | 0.49 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.48 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.48 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.48 |
| ▸ | CHRNG | P07510 | 1/20 | 0.48 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.48 |
| ▸ | CHRND | Q07001 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5686204 | 1.00 | LTA4H (0.49) | LTA4HCHRNA3CHRNB4CHRNA1CHRNG | |
| SCHEMBL4497884 | 0.84 | MAP2K1 (0.50) | CHRNA3CHRNB4CHRNA1CHRNGCHRNB1 | |
| SCHEMBL4498763 | 0.84 | MAP2K1 (0.50) | CHRNA3CHRNB4CHRNA1CHRNGCHRNB1 | |
| SCHEMBL4492858 | 0.83 | CHRNB4 (0.53) | CHRNA3CHRNB4CHRNB2CHRNA4 | |
| SCHEMBL4310605 | 0.75 | LTA4H (0.72) | LTA4HCHRNA3CHRNB4CHRNA1CHRNG | |
| SCHEMBL4310599 | 0.75 | LTA4H (0.72) | LTA4HCHRNA3CHRNB4CHRNA1CHRNG | |
| SCHEMBL8551635 | 0.75 | CHRNB4 (0.67) | CHRNA3CHRNB4CHRNA1CHRNGCHRNB1 | |
| SCHEMBL5155735 | 0.73 | LTA4H (0.62) | LTA4HCHRNA3 | |
| SCHEMBL5155727 | 0.73 | LTA4H (0.62) | LTA4HCHRNA3 | |
| SCHEMBL30344019 | 0.73 | CHRNB4 (0.66) | LTA4HCHRNA3CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648464-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINCARBOXAMID DERIVATIVES AND RELATED COMPOUNDS AS T-CELL ACTIVATION INHIBITORS FOR THE TREATMENT OF INFLAMMATIONS | AMGEN INC. (US) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005009443-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF T CELL ACTIVATION FOR THE TREATMENT OF INFLAMMATORY DISEASES | AMGEN INC. (US) | 2005-02-03 | — | — | WO | disclosed |