Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 2/20 | 0.50 |
| ▸ | JAK3 | P52333 | 2/20 | 0.48 |
| ▸ | BTK | Q06187 | 2/20 | 0.48 |
| ▸ | KDR | P35968 | 7/20 | 0.46 |
| ▸ | LCK | P06239 | 2/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 5/20 | 0.46 |
| ▸ | EGFR | P00533 | 4/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5689288 | 0.93 | CSF1R (0.48) | CSF1RJAK3BTKKDRLCK | |
| SCHEMBL5686060 | 0.93 | KDR (0.54) | CSF1RJAK3BTKKDRLCK | |
| SCHEMBL4496504 | 0.91 | KDR (0.52) | CSF1RJAK3BTKKDRLCK | |
| SCHEMBL4503003 | 0.89 | MET (0.45) | CSF1RJAK3BTKKDRLCK | |
| SCHEMBL5689079 | 0.88 | KDR (0.47) | CSF1RKDRLCKMAPK14SRC | |
| SCHEMBL4497531 | 0.88 | KDR (0.47) | CSF1RKDRLCKMAPK14SRC | |
| SCHEMBL4481044 | 0.87 | EGFR (0.47) | JAK3BTKKDRLCKMAPK14 | |
| SCHEMBL5686145 | 0.85 | TNK2 (0.50) | JAK3BTKKDRLCKMAPK14 | |
| SCHEMBL4493427 | 0.84 | CSF1R (0.47) | CSF1RJAK3BTKKDRLCK | |
| SCHEMBL4496395 | 0.84 | TNK2 (0.56) | JAK3BTKKDRLCKMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648464-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINCARBOXAMID DERIVATIVES AND RELATED COMPOUNDS AS T-CELL ACTIVATION INHIBITORS FOR THE TREATMENT OF INFLAMMATIONS | AMGEN INC. (US) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005009443-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF T CELL ACTIVATION FOR THE TREATMENT OF INFLAMMATORY DISEASES | AMGEN INC. (US) | 2005-02-03 | — | — | WO | disclosed |