Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 18/20 | 0.71 |
| ▸ | MAPK13 | O15264 | 17/20 | 0.71 |
| ▸ | MAPK12 | P53778 | 17/20 | 0.71 |
| ▸ | MAPK11 | Q15759 | 17/20 | 0.71 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.53 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.53 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.53 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.53 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.53 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CIT | O14578 | 1/20 | 0.47 |
| ▸ | GAK | O14976 | 1/20 | 0.47 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | GMNN | O75496 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4914367 | 0.83 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11CSNK1D | |
| SCHEMBL8485057 | 0.83 | MAPK14 (0.70) | MAPK14MAPK13MAPK12MAPK11CSNK1D | |
| SCHEMBL4918482 | 0.81 | MAPK14 (0.67) | MAPK14MAPK13MAPK12MAPK11CSNK1D | |
| SCHEMBL27639359 | 0.78 | FAAH (0.56) | MAPK14MAPK13MAPK12MAPK11ALDH1A1 | |
| SCHEMBL27595420 | 0.78 | MAPK14 (0.59) | MAPK14MAPK13MAPK12MAPK11ALDH1A1 | |
| SCHEMBL27335380 | 0.77 | MAPK14 (0.71) | MAPK14MAPK13MAPK12MAPK11CSNK1D | |
| SCHEMBL8483581 | 0.76 | MAPK14 (0.61) | MAPK14MAPK13MAPK12MAPK11ALOX5 | |
| SCHEMBL8487390 | 0.76 | MAPK14 (0.60) | MAPK14MAPK13MAPK12MAPK11CSNK1D | |
| SCHEMBL4593942 | 0.75 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11CSNK1D | |
| SCHEMBL27335372 | 0.74 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11CSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030078274-A1 | Method of reducing neuronal injury or apoptosis | LIPTON STUART A (US) | 2003-04-24 | — | — | US | claimed |
| EP-1196167-B1 | Use of p38 MAPK inhibitors in the treatment of ophthalmic conditions | LIPTON STUART A (US) | 2006-04-19 | — | — | EP | disclosed |
| US-20030078274-A1 | Method of reducing neuronal injury or apoptosis | LIPTON STUART A (US) | 2003-04-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030078274-A1 | Method of reducing neuronal injury or apoptosis | GAP43, DCX, NLN | MAPK14 40/4885MAPK13 129/4885MAPK12 42/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.