SCHEMBL5688259

SCHEMBL5688259

CC(=O)Nc1ccc(-c2ccc(C(O)(c3cn(C(c4ccccc4)(c4ccccc4)c4ccccc4)cn3)C(C)C)cc2)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP17A1 P05093 8/20 0.50
CYP3A4 P08684 3/20 0.50
OGT O15294 1/20 0.40
HTT P42858 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
ACSS2 Q9NR19 1/20 0.38
JAK2 O60674 2/20 0.38
JAK3 P52333 1/20 0.38
ALDH1A1 P00352 3/20 0.37
MAPT P10636 3/20 0.37
MEN1 O00255 2/20 0.37
HPGD P15428 2/20 0.37
KMT2A Q03164 2/20 0.37
SIRT2 Q8IXJ6 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
RXFP1 Q9HBX9 1/20 0.37
KDM4E B2RXH2 1/20 0.37
CYP2C19 P33261 1/20 0.37
POLB P06746 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5689005 0.92 CYP17A1 (0.55) CYP17A1CYP3A4SMN1; SMN2ADAMTS4NPC1
SCHEMBL5688723 0.90 CYP17A1 (0.44) CYP17A1CYP3A4ACSS2SIRT2ADAMTS4
SCHEMBL5688662 0.89 CYP17A1 (0.40) CYP17A1CYP3A4SMN1; SMN2ACSS2ALDH1A1
SCHEMBL5688641 0.89 JAK2 (0.41) CYP17A1CYP3A4ACSS2JAK2JAK3
SCHEMBL5689052 0.88 CYP3A4 (0.42) CYP17A1CYP3A4ALDH1A1HPGDRXFP1
SCHEMBL4030863 0.88 CYP17A1 (0.52) CYP17A1CYP3A4OGTACSS2MAPT
SCHEMBL5691077 0.87 CYP17A1 (0.39) CYP17A1CYP3A4ACSS2SIRT2POLB
SCHEMBL5690727 0.86 CYP17A1 (0.47) CYP17A1CYP3A4SMN1; SMN2ALDH1A1MAPT
SCHEMBL5688707 0.86 CYP17A1 (0.40) CYP17A1CYP3A4SIRT2KDM4E
SCHEMBL5689078 0.85 CYP17A1 (0.56) CYP17A1CYP3A4JAK2SIRT2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1227086-B1 1-SUBSTITUTED PHENYL-1-(1H-IMIDAZOL-4-YL) ALCOHOLS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF TAKEDA PHARMACEUTICAL (JP) 2006-03-29 EP disclosed
US-6518257-B1 1-substituted phenyl-1-(1h-imidazol-4-yl) alcohols, process for producing the same and use thereof TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2003-02-11 US disclosed
EP-1227086-A1 1-SUBSTITUTED PHENYL-1-(1H-IMIDAZOL-4-YL) ALCOHOLS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF Takeda Chemical Industries, Ltd. (JP) 2002-07-31 EP disclosed