SCHEMBL5688342

SCHEMBL5688342

COc1ccc(-c2ccccc2)cc1C(O)(c1c[nH]cn1)C(C)C

nearest known ligand 0.44

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CYP17A1 P05093 9/20 0.44
CYP3A4 P08684 9/20 0.40
NR3C1 P04150 1/20 0.36
PGR P06401 1/20 0.36
NR3C2 P08235 1/20 0.36
AAK1 Q2M2I8 1/20 0.35
KIT P10721 1/20 0.35
ACLY P53396 1/20 0.35
IDO1 P14902 1/20 0.35
CTSA P10619 1/20 0.35
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5688327 0.81 CYP17A1 (0.63) CYP17A1CYP3A4KITCYP2C9CYP2C19
SCHEMBL5690835 0.81 CYP3A4 (0.41) CYP17A1CYP3A4CTSACYP2C9CYP2C19
SCHEMBL5688522 0.79 CYP17A1 (0.57) CYP17A1CYP3A4CYP2C9
SCHEMBL5690534 0.78 CYP17A1 (0.60) CYP17A1CYP3A4
SCHEMBL5690859 0.77 CYP17A1 (0.50) CYP17A1CYP3A4
SCHEMBL5688348 0.77 CYP17A1 (0.64) CYP17A1CYP3A4CYP2C9CYP2C19
SCHEMBL4026821 0.77 CYP17A1 (0.47) CYP17A1CYP3A4CYP2C9CYP2C19
SCHEMBL5691092 0.76 CYP17A1 (0.42) CYP17A1CYP3A4IDO1CYP2C9CYP2C19
SCHEMBL5688968 0.76 PTPN5 (0.46) CYP17A1CYP3A4CTSACYP2C9CYP2C19
SCHEMBL5689408 0.74 CYP3A4 (0.54) CYP17A1CYP3A4CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1227086-B1 1-SUBSTITUTED PHENYL-1-(1H-IMIDAZOL-4-YL) ALCOHOLS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF TAKEDA PHARMACEUTICAL (JP) 2006-03-29 EP disclosed
US-6518257-B1 1-substituted phenyl-1-(1h-imidazol-4-yl) alcohols, process for producing the same and use thereof TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2003-02-11 US disclosed
EP-1227086-A1 1-SUBSTITUTED PHENYL-1-(1H-IMIDAZOL-4-YL) ALCOHOLS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF Takeda Chemical Industries, Ltd. (JP) 2002-07-31 EP disclosed