Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.67 |
| ▸ | GRM8 | O00222 | 1/20 | 0.50 |
| ▸ | GRM6 | O15303 | 1/20 | 0.50 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.50 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 1/20 | 0.50 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.50 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.50 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.50 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.50 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.50 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.50 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.50 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.50 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.50 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL1191627 | 0.89 | GSR (0.83) | GSRGRM8GRM6GRIN2DGRIN3B | |
| Lysine SCHEMBL1191629 | 0.89 | GSR (0.83) | GSRGRM8GRM6GRIN2DGRIN3B | |
| Lysine SCHEMBL5246406 | 0.89 | GSR (0.83) | GSRGRM8GRM6GRIN2DGRIN3B | |
| Lysine SCHEMBL5246411 | 0.89 | GSR (0.83) | GSRGRM8GRM6GRIN2DGRIN3B | |
| Lysine SCHEMBL4956653 | 0.88 | GSR (0.74) | GSRGRM8GRM6GRIN2DGRIN3B | |
| Lysine SCHEMBL5501369 | 0.88 | GSR (0.80) | GSRGRM8GRM6GRIN2DGRIN3B | |
| Lysine SCHEMBL8986786 | 0.88 | GSR (0.80) | GSRGRM8GRM6GRIN2DGRIN3B | |
| Lysine SCHEMBL5501368 | 0.88 | GSR (0.80) | GSRGRM8GRM6GRIN2DGRIN3B | |
| Lysine SCHEMBL8986785 | 0.88 | GSR (0.80) | GSRGRM8GRM6GRIN2DGRIN3B | |
| Lysine SCHEMBL8836492 | 0.88 | GSR (0.80) | GSRGRM8GRM6GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2601297-B1 | METHOD FOR TARGETED GENOMIC EVENTS IN ALGAE | CELLECTIS (FR) | 2020-09-16 | — | — | EP | disclosed |
| US-20130164850-A1 | METHOD FOR TARGETED GENOMIC EVENTS IN ALGAE | CELLECTIS (FR) | 2013-06-27 | — | — | US | disclosed |
| EP-2601297-A2 | METHOD FOR TARGETED GENOMIC EVENTS IN ALGAE | Cellectis (FR) | 2013-06-12 | — | — | EP | disclosed |
| WO-2012017329-A2 | METHOD FOR TARGETED GENOMIC EVENTS IN ALGAE | CELLECTIS S.A. (FR) | 2012-02-09 | — | — | WO | disclosed |
| US-20110045593-A1 | Transgenically mitigating the establishment and spread of transgenic algae in natural ecosystems by suppressing the activity of carbonic anhydrase | TransAlgae (Israel) Ltd. (IL) | 2011-02-24 | — | — | US | disclosed |
| US-6429229-B1 | ADMINISTERING TO TREAT PATHOLOGIES ASSOCIATED WITH SILENT NEURONS (BLADDER, BILE DUCTS, AND DIGESTIVE SYSTEM) | CHIESI S.A. (FR) | 2002-08-06 | — | — | US | disclosed |