Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.74 |
| ▸ | ARG2 | P78540 | 5/20 | 0.47 |
| ▸ | ARG1 | P05089 | 3/20 | 0.47 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.46 |
| ▸ | NOS2 | P35228 | 5/20 | 0.42 |
| ▸ | NOS1 | P29475 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | NOS3 | P29474 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | GRM8 | O00222 | 1/20 | 0.41 |
| ▸ | GRM6 | O15303 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL27690087 | 0.96 | GSR (0.69) | GSRARG2ARG1RNPEPNOS2 | |
| Ornithine SCHEMBL10560893 | 0.94 | GSR (0.64) | GSRARG2ARG1NOS2NOS1 | |
| Ornithine Aketoglutarate SCHEMBL27844740 | 0.93 | GSR (0.68) | GSRARG2ARG1RNPEPNOS2 | |
| SCHEMBL3423971 | 0.88 | GSR (0.59) | GSRARG2ARG1NOS2NOS1 | |
| SCHEMBL17262412 | 0.88 | GSR (0.59) | GSRARG2ARG1NOS2NOS1 | |
| SCHEMBL259006 | 0.88 | GSR (0.59) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL28046911 | 0.88 | GSR (0.95) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL568843 | 0.88 | GSR (0.67) | GSRARG2ARG1RNPEPCYP1A2 | |
| Lysine SCHEMBL28235018 | 0.88 | GSR (0.67) | GSRARG2ARG1RNPEPNOS2 | |
| Lysine SCHEMBL93725 | 0.87 | GSR (0.77) | GSRARG2ARG1RNPEPNOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080009028-A1 | Tissue Embedding Matrix | THE RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC. (US) | 2008-01-10 | — | — | US | claimed |
| US-8257942-B2 | Tissue embedding matrix | THE RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC. (US) | 2012-09-04 | — | — | US | disclosed |
| US-8257942-B2 | Tissue embedding matrix | THE RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC. (US) | 2012-09-04 | — | — | US | disclosed |
| US-20080009028-A1 | Tissue Embedding Matrix | THE RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC. (US) | 2008-01-10 | — | — | US | disclosed |
| US-20080009028-A1 | Tissue Embedding Matrix | THE RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC. (US) | 2008-01-10 | — | — | US | disclosed |
| US-4861705-A | Method for removing components of biological fluids | YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD. (IL) | 1989-08-29 | — | — | US | disclosed |
| EP-0326111-A2 | Peptide derivatives rendered immunogenic when administered with alum as an adjuvant | New York Blood Center, Inc. (US) | 1989-08-02 | — | — | EP | disclosed |
| US-4732811-A | Agarose-polyaldehyde beads and their biological application affinity chromatography, hemoperfusion, cell separation, etc. | YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD. (IL) | 1988-03-22 | — | — | US | disclosed |
| EP-0087786-B1 | AGAROSE-POLYALDEHYDE BEADS, PROCESS FOR THEIR PRODUCTION AND THEIR USE | YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD. (IL) | 1987-06-24 | — | — | EP | disclosed |
| EP-0089365-A4 | New Dye or Fluorescent polymers and their use as labels in immunoassay systems. | HENRY ROBERT P | 1985-08-21 | — | — | EP | disclosed |
| US-4452886-A | Novel photon absorbing or emitting polymers and their use as reagents in immunoassay systems | PHOTEST DIAGNOSTICS, INC. A CORPORATION OF DE | 1984-06-05 | — | — | US | disclosed |
| EP-0089365-A1 | New Dye or Fluorescent polymers and their use as labels in immunoassay systems. | PHOTEST DIAGNOSTICS, INC. (US) | 1983-09-28 | — | — | EP | disclosed |
| EP-0087786-A1 | Agarose-polyaldehyde beads, process for their production and their use | YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD. (IL) | 1983-09-07 | — | — | EP | disclosed |
| WO-1983001064-A1 | NOVEL PHOTON ABSORBING OR EMITTING POLYMERS AND THEIR USE AS REAGENTS IN IMMUNOASSAY SYSTEMS | HENRY, ROBERT, P. | 1983-03-31 | — | — | WO | disclosed |