Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 2/20 | 0.53 |
| ▸ | CDK2 | P24941 | 2/20 | 0.53 |
| ▸ | CDK9 | P50750 | 2/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | JAK3 | P52333 | 1/20 | 0.50 |
| ▸ | BTK | Q06187 | 1/20 | 0.50 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.50 |
| ▸ | PTK2 | Q05397 | 8/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 3/20 | 0.43 |
| ▸ | YES1 | P07947 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | TTK | P33981 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4508576 | 0.93 | LCK (0.58) | CCNT1CDK2CDK9CCNE1LCK | |
| SCHEMBL5686350 | 0.92 | LCK (0.55) | CCNT1CDK2CDK9CCNE1LCK | |
| SCHEMBL4501894 | 0.90 | CCNT1 (0.46) | CCNT1CDK2CDK9CCNE1LCK | |
| SCHEMBL4497894 | 0.87 | CCNT1 (0.43) | CCNT1CDK2CDK9CCNE1LCK | |
| SCHEMBL4484444 | 0.85 | LCK (0.64) | CCNT1CDK2CDK9CCNE1LCK | |
| SCHEMBL4505987 | 0.83 | LCK (0.48) | CCNT1CDK2CDK9CCNE1LCK | |
| SCHEMBL4500587 | 0.83 | LCK (0.61) | LCKJAK3BTKTNK2PTK2 | |
| SCHEMBL4500046 | 0.81 | LCK (0.47) | CCNT1CDK2CDK9CCNE1LCK | |
| SCHEMBL4565004 | 0.80 | ULK1 (0.58) | CDK2LCKJAK3BTKTNK2 | |
| SCHEMBL4484056 | 0.79 | LCK (0.56) | CCNT1CDK2CDK9LCKJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648464-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINCARBOXAMID DERIVATIVES AND RELATED COMPOUNDS AS T-CELL ACTIVATION INHIBITORS FOR THE TREATMENT OF INFLAMMATIONS | AMGEN INC. (US) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005009443-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF T CELL ACTIVATION FOR THE TREATMENT OF INFLAMMATORY DISEASES | AMGEN INC. (US) | 2005-02-03 | — | — | WO | disclosed |