Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.49 |
| ▸ | INSR | P06213 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 5/20 | 0.44 |
| ▸ | KDR | P35968 | 4/20 | 0.44 |
| ▸ | EGFR | P00533 | 6/20 | 0.43 |
| ▸ | LCK | P06239 | 2/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 2/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.41 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4507920 | 0.93 | AXL (0.49) | AXLINSRCSF1RKDREGFR | |
| SCHEMBL4489929 | 0.91 | AXL (0.57) | AXLINSRCSF1RKDREGFR | |
| SCHEMBL4499318 | 0.90 | AXL (0.56) | AXLINSRCSF1RKDREGFR | |
| SCHEMBL5689284 | 0.90 | AXL (0.47) | AXLINSRCSF1RKDREGFR | |
| SCHEMBL4495452 | 0.89 | EGFR (0.48) | AXLINSRCSF1RKDREGFR | |
| SCHEMBL4500736 | 0.89 | AXL (0.49) | AXLINSRCSF1RKDREGFR | |
| SCHEMBL5686178 | 0.89 | CSF1R (0.52) | AXLINSRCSF1RKDREGFR | |
| SCHEMBL4480188 | 0.89 | AXL (0.59) | AXLINSRKDREGFRBTK | |
| SCHEMBL4494805 | 0.86 | AXL (0.52) | AXLINSRCSF1RKDREGFR | |
| SCHEMBL4495092 | 0.85 | AXL (0.51) | AXLINSRCSF1RKDREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648464-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINCARBOXAMID DERIVATIVES AND RELATED COMPOUNDS AS T-CELL ACTIVATION INHIBITORS FOR THE TREATMENT OF INFLAMMATIONS | AMGEN INC. (US) | 2006-04-26 | — | — | EP | claimed |
| WO-2005009443-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF T CELL ACTIVATION FOR THE TREATMENT OF INFLAMMATORY DISEASES | AMGEN INC. (US) | 2005-02-03 | — | — | WO | claimed |