Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 2/20 | 0.52 |
| ▸ | KDR | P35968 | 4/20 | 0.48 |
| ▸ | LCK | P06239 | 2/20 | 0.48 |
| ▸ | SRC | P12931 | 2/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 4/20 | 0.45 |
| ▸ | JAK3 | P52333 | 2/20 | 0.45 |
| ▸ | AXL | P30530 | 4/20 | 0.45 |
| ▸ | INSR | P06213 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 5/20 | 0.43 |
| ▸ | MET | P08581 | 3/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.42 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4507920 | 0.95 | AXL (0.49) | CSF1RKDRLCKSRCMAPK14 | |
| SCHEMBL4495452 | 0.93 | EGFR (0.48) | CSF1RKDRLCKSRCMAPK14 | |
| SCHEMBL4494805 | 0.92 | AXL (0.52) | CSF1RKDRLCKSRCMAPK14 | |
| SCHEMBL4495092 | 0.91 | AXL (0.51) | CSF1RKDRLCKSRCMAPK14 | |
| SCHEMBL4494947 | 0.90 | INSR (0.54) | KDRBTKJAK3AXLINSR | |
| SCHEMBL5689296 | 0.89 | AXL (0.49) | CSF1RKDRLCKSRCBTK | |
| SCHEMBL4489929 | 0.87 | AXL (0.57) | CSF1RKDRLCKBTKJAK3 | |
| SCHEMBL4499318 | 0.86 | AXL (0.56) | CSF1RKDRLCKBTKAXL | |
| SCHEMBL5689284 | 0.86 | AXL (0.47) | CSF1RKDRLCKSRCBTK | |
| SCHEMBL4503003 | 0.86 | MET (0.45) | CSF1RKDRLCKSRCMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648464-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINCARBOXAMID DERIVATIVES AND RELATED COMPOUNDS AS T-CELL ACTIVATION INHIBITORS FOR THE TREATMENT OF INFLAMMATIONS | AMGEN INC. (US) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005009443-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF T CELL ACTIVATION FOR THE TREATMENT OF INFLAMMATORY DISEASES | AMGEN INC. (US) | 2005-02-03 | — | — | WO | disclosed |