Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 17/20 | 0.60 |
| ▸ | TUBB4A | P04350 | 14/20 | 0.60 |
| ▸ | TUBB | P07437 | 14/20 | 0.60 |
| ▸ | TUBA3C | P0DPH7 | 14/20 | 0.60 |
| ▸ | TUBA1B | P68363 | 14/20 | 0.60 |
| ▸ | TUBA4A | P68366 | 14/20 | 0.60 |
| ▸ | TUBB4B | P68371 | 14/20 | 0.60 |
| ▸ | TUBB3 | Q13509 | 14/20 | 0.60 |
| ▸ | TUBB2A | Q13885 | 14/20 | 0.60 |
| ▸ | TUBB8 | Q3ZCM7 | 14/20 | 0.60 |
| ▸ | TUBA3E | Q6PEY2 | 14/20 | 0.60 |
| ▸ | TUBA1A | Q71U36 | 14/20 | 0.60 |
| ▸ | TUBA1C | Q9BQE3 | 14/20 | 0.60 |
| ▸ | TUBB6 | Q9BUF5 | 14/20 | 0.60 |
| ▸ | TUBB2B | Q9BVA1 | 14/20 | 0.60 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.51 |
| ▸ | NQO2 | P16083 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5687761 | 1.00 | TUBB1 (0.60) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL5687768 | 1.00 | TUBB1 (0.60) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL38654906 | 0.88 | TUBB1 (0.72) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL5686615 | 0.88 | TUBB1 (0.72) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL5686608 | 0.88 | TUBB1 (0.72) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL5686624 | 0.88 | TUBB1 (0.72) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL5687379 | 0.87 | TUBB1 (0.70) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL5686486 | 0.86 | TUBB1 (0.50) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL5686444 | 0.81 | TUBB1 (0.62) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL5686435 | 0.81 | TUBB1 (0.62) | TUBB1TUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060160773-A1 | Combretastatin derivatives with cytotoxic action | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2006-07-20 | — | — | US | claimed |
| EP-1646616-A2 | COMBRETASTATIN DERIVATIVES WITH CYTOTOXIC ACTION | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 2006-04-19 | — | — | EP | claimed |
| WO-2005007635-A2 | COMBRETASTATIN DERIVATIVES WITH CYTOTOXIC ACTION | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2005-01-27 | — | — | WO | claimed |
| EP-1646616-A2 | COMBRETASTATIN DERIVATIVES WITH CYTOTOXIC ACTION | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 2006-04-19 | — | — | EP | disclosed |
| WO-2005007635-A2 | COMBRETASTATIN DERIVATIVES WITH CYTOTOXIC ACTION | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2005-01-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060160773-A1 | Combretastatin derivatives with cytotoxic action | TUBB, TUBB1, TYMS | TUBB1 2/4885TUBB4A 6/4885TUBB 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.