Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5692121 | 0.83 | NR1H2 (0.41) | MEN1GAAKMT2AHPGDTSHR | |
| SCHEMBL5692443 | 0.83 | — | — | |
| SCHEMBL6553688 | 0.80 | MEN1 (0.33) | MEN1GAAKMT2A | |
| SCHEMBL5692212 | 0.80 | TP53 (0.31) | — | |
| SCHEMBL5692206 | 0.79 | MEN1 (0.32) | MEN1GAAKMT2A | |
| SCHEMBL5692084 | 0.78 | NR1H2 (0.33) | MEN1GAAKMT2A | |
| SCHEMBL5692425 | 0.77 | MEN1 (0.31) | MEN1GAAKMT2A | |
| SCHEMBL5692063 | 0.76 | MEN1 (0.30) | MEN1GAAKMT2A | |
| SCHEMBL8576186 | 0.75 | NR1H2 (0.38) | MEN1GAAKMT2A | |
| SCHEMBL5692525 | 0.74 | ALDH1A1 (0.32) | MEN1GAAKMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1468692-B1 | Use of 2,6-di-alkyl-4-silyl-phenols for treating xanthoma | MERRELL PHARMA INC (US) | 2006-04-26 | — | — | EP | disclosed |
| EP-0732928-B1 | METHOD OF LOWERING SERUM CHOLESTEROL LEVELS WITH 2,6-DI-ALKYL-4-SILYL-PHENOLS | MERRELL PHARMA INC (US) | 2004-12-22 | — | — | EP | disclosed |
| EP-1468692-A2 | Use of 2,6-di-alkyl-4-silyl-phenols for treating xanthoma | MERRELL PHARMACEUTICALS INC. (US) | 2004-10-20 | — | — | EP | disclosed |
| EP-1468693-A2 | Use of 2,6-di -alkyl-4-silyl-phenols for treating diabetes mellitus | MERRELL PHARMACEUTICALS INC. (US) | 2004-10-20 | — | — | EP | disclosed |
| US-5795876-A | ANTIINFLAMMATORY AGENTS | HOECHST MARION ROUSSSEL, INC. (US) | 1998-08-18 | — | — | US | disclosed |
| US-5532400-A | 2,6-di-alkyl-4-silyl-phenols as antiatheroscelerotic agents | MERRELL PHARMACEUTICALS INC. (US) | 1996-07-02 | — | — | US | disclosed |
| EP-0464852-B1 | Novel 2,6-di-alkyl-4-silyl-phenols as antiatherosclerotic agents and as antioxidants | MERRELL DOW PHARMA (US) | 1996-03-20 | — | — | EP | disclosed |
| US-5155250-A | 2,6-DI-ALKYL-4-SILYL-PHENOLS AS ANTIATHEROSCEROTIC AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-10-13 | — | — | US | disclosed |
| EP-0464852-A1 | Novel 2,6-di-alkyl-4-silyl-phenols as antiatherosclerotic agents and as antioxidants | MERRELL PHARMACEUTICALS INC. (US) | 1992-01-08 | — | — | EP | disclosed |