Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.48 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.42 |
| ▸ | GBA1 | P04062 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29760303 | 1.00 | SIGMAR1 (0.48) | SIGMAR1GRIN1GRIN2BMAPTFUCA1 | |
| SCHEMBL17231981 | 0.84 | SIGMAR1 (0.49) | SIGMAR1 | |
| SCHEMBL29774325 | 0.83 | GAA (0.47) | SIGMAR1GRIN1GRIN2BGBA1 | |
| SCHEMBL13978050 | 0.80 | GBA1 (0.43) | SIGMAR1GRIN1GRIN2BGBA1 | |
| SCHEMBL24755096 | 0.79 | HDAC1 (0.39) | — | |
| SCHEMBL7044789 | 0.79 | ACE (0.52) | SIGMAR1GRIN1GRIN2B | |
| SCHEMBL7044790 | 0.79 | ACE (0.52) | SIGMAR1GRIN1GRIN2B | |
| SCHEMBL7044785 | 0.79 | ACE (0.52) | SIGMAR1GRIN1GRIN2B | |
| SCHEMBL14012100 | 0.79 | PRCP (0.49) | MAPT | |
| SCHEMBL13079294 | 0.77 | SIGMAR1 (0.42) | SIGMAR1GRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1528923-B1 | N-((3-OXO-2,3-DIHYDRO-1H-ISOINDOL-1-YL)ACETYL)GUANIDINE DERIVATIVES AS NHE1-INHIBITORS FOR THE TREATMENT OF INFARCTION AND ANGINA PECTORIS | SANOFI AVENTIS DEUTSCHLAND (DE) | 2006-05-03 | — | — | EP | disclosed |