SCHEMBL5693176

SCHEMBL5693176

COC(=O)[C@H](C=Cc1ccccc1)OC

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.46
TDP1 Q9NUW8 3/20 0.46
KMT2A Q03164 2/20 0.46
ALDH1A1 P00352 3/20 0.45
GLA P06280 1/20 0.43
CNR2 P34972 1/20 0.43
HDAC3 O15379 2/20 0.42
HDAC4 P56524 2/20 0.42
HDAC1 Q13547 2/20 0.42
HDAC2 Q92769 2/20 0.42
HDAC8 Q9BY41 2/20 0.42
HDAC6 Q9UBN7 2/20 0.42
MAPT P10636 2/20 0.41
TNKS O95271 1/20 0.41
HCAR2 Q8TDS4 1/20 0.41
HDAC7 Q8WUI4 1/20 0.41
HDAC10 Q969S8 1/20 0.41
HDAC11 Q96DB2 1/20 0.41
TNKS2 Q9H2K2 1/20 0.41
HDAC9 Q9UKV0 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3062710 1.00 CYP1A2 (0.46) CYP1A2TDP1KMT2AALDH1A1GLA
SCHEMBL3070944 0.86 CYP1A2 (0.53) CYP1A2TDP1KMT2AALDH1A1GLA
SCHEMBL3070951 0.86 CYP1A2 (0.53) CYP1A2TDP1KMT2AALDH1A1GLA
SCHEMBL3070948 0.86 CYP1A2 (0.53) CYP1A2TDP1KMT2AALDH1A1GLA
SCHEMBL3070941 0.86 CYP1A2 (0.53) CYP1A2TDP1KMT2AALDH1A1GLA
SCHEMBL5693154 0.85 CNR2 (0.43) CYP1A2TDP1KMT2AALDH1A1CNR2
SCHEMBL5693157 0.85 CNR2 (0.43) CYP1A2TDP1KMT2AALDH1A1CNR2
SCHEMBL3073240 0.82 POLB (0.43) CYP1A2TDP1KMT2AALDH1A1CNR2
SCHEMBL11988772 0.81 CYP1A2 (0.47) CYP1A2TDP1KMT2AALDH1A1GLA
SCHEMBL11584234 0.81 TDP1 (0.50) CYP1A2TDP1KMT2AALDH1A1GLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1658260-A1 BUTENOIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND USE FOR THE TREATMENT OF DYSLIPIDAEMIA, ATHEROSCLEROSIS AND DIABETES Merk Patent Gmbh (DE) 2006-05-24 EP claimed
WO-2005014521-A1 BUTENOIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND USE FOR THE TREATMENT OF DYSLIPIDAEMIA, ATHEROSCLEROSIS AND DIABETES MERK PATENT GMBH (DE) 2005-02-17 WO claimed