SCHEMBL5693157

SCHEMBL5693157

COC(=O)[C@H](C=Cc1ccccc1)Oc1ccccc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
CYP1A2 P05177 1/20 0.42
KMT2A Q03164 2/20 0.42
ALDH1A1 P00352 2/20 0.42
MMP1 P03956 2/20 0.42
MMP2 P08253 2/20 0.42
MMP9 P14780 2/20 0.42
NPC1 O15118 3/20 0.41
RAB9A P51151 3/20 0.41
SMN1; SMN2 Q16637 3/20 0.41
MAOB P27338 2/20 0.41
PPARG P37231 1/20 0.41
PPARA Q07869 1/20 0.41
EGFR P00533 1/20 0.41
MAPT P10636 2/20 0.41
MEN1 O00255 1/20 0.41
HSPD1 P10809 1/20 0.41
TNFRSF1A P19438 1/20 0.41
HSPE1 P61604 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5693154 1.00 CNR2 (0.43) CNR2TDP1CYP1A2KMT2AALDH1A1
SCHEMBL3070928 0.87 NOS3 (0.49) CYP1A2KMT2ANPC1RAB9AMAOB
SCHEMBL11988775 0.87 NOS3 (0.49) CYP1A2KMT2ANPC1RAB9AMAOB
SCHEMBL3062710 0.85 CYP1A2 (0.46) CNR2TDP1CYP1A2KMT2AALDH1A1
SCHEMBL5693176 0.85 CYP1A2 (0.46) CNR2TDP1CYP1A2KMT2AALDH1A1
SCHEMBL11988773 0.85 RAB9A (0.47) CNR2TDP1KMT2AALDH1A1NPC1
SCHEMBL3074419 0.83 CYP1A2 (0.51) CNR2TDP1CYP1A2KMT2AALDH1A1
SCHEMBL3074420 0.83 CYP1A2 (0.51) CNR2TDP1CYP1A2KMT2AALDH1A1
SCHEMBL3074423 0.83 CYP1A2 (0.51) CNR2TDP1CYP1A2KMT2AALDH1A1
SCHEMBL3074422 0.83 CYP1A2 (0.51) CNR2TDP1CYP1A2KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1658260-A1 BUTENOIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND USE FOR THE TREATMENT OF DYSLIPIDAEMIA, ATHEROSCLEROSIS AND DIABETES Merk Patent Gmbh (DE) 2006-05-24 EP claimed
WO-2005014521-A1 BUTENOIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND USE FOR THE TREATMENT OF DYSLIPIDAEMIA, ATHEROSCLEROSIS AND DIABETES MERK PATENT GMBH (DE) 2005-02-17 WO claimed