Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.69 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | GPR174 | Q9BXC1 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 5/20 | 0.54 |
| ▸ | HTT | P42858 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23884700 | 0.94 | MAPT (0.59) | MAPTALDH1A1ALDH1A3SMN1; SMN2NPC1 | |
| SCHEMBL5693165 | 0.84 | MAPT (0.62) | MAPTALDH1A1ALDH1A3SMN1; SMN2LMNA | |
| SCHEMBL27917040 | 0.84 | ALDH1A1 (0.76) | MAPTALDH1A1ALDH1A3SMN1; SMN2LMNA | |
| SCHEMBL1419188 | 0.82 | ALDH1A1 (1.00) | MAPTALDH1A1ALDH1A3SMN1; SMN2NPC1 | |
| SCHEMBL16123482 | 0.82 | MAPT (0.60) | MAPTALDH1A1SMN1; SMN2NPC1GPR174 | |
| SCHEMBL5989854 | 0.82 | MAPT (0.72) | MAPTALDH1A1SMN1; SMN2NPC1GPR174 | |
| SCHEMBL12890005 | 0.81 | GRM5 (0.62) | MAPTALDH1A1SMN1; SMN2GPR174LMNA | |
| SCHEMBL1418324 | 0.81 | ALDH1A1 (0.97) | MAPTALDH1A1ALDH1A3SMN1; SMN2NPC1 | |
| SCHEMBL29912570 | 0.81 | ALDH1A1 (0.97) | MAPTALDH1A1ALDH1A3SMN1; SMN2NPC1 | |
| SCHEMBL22147373 | 0.80 | MAPT (0.66) | MAPTALDH1A1ALDH1A3SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060281789-A1 | Protein kinase inhibitors | KYOWA HAKKO KOGYO CO., LTD (JP) | 2006-12-14 | — | — | US | disclosed |
| EP-1650194-A1 | PROTEIN KINASE INHIBITOR | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-04-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060281789-A1 | Protein kinase inhibitors | MAP3K20, MAP3K1, MAP3K19 | MAPT 1336/4885ALDH1A1 2999/4885ALDH1A3 4253/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.