Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | MAOB | P27338 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | XBP1 | P17861 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5068228 | 0.97 | KMT2A (0.50) | KMT2AMEN1RAB9ANPC1MAOB | |
| SCHEMBL5068230 | 0.97 | KMT2A (0.50) | KMT2AMEN1RAB9ANPC1MAOB | |
| SCHEMBL5066571 | 0.86 | KMT2A (0.64) | KMT2AMEN1RAB9ANPC1MAOB | |
| SCHEMBL5070804 | 0.86 | POLB (0.40) | KMT2AMEN1MAPTALDH1A1LMNA | |
| SCHEMBL5069179 | 0.86 | POLB (0.40) | KMT2AMEN1MAPTALDH1A1LMNA | |
| SCHEMBL5069177 | 0.86 | POLB (0.40) | KMT2AMEN1MAPTALDH1A1LMNA | |
| SCHEMBL5068274 | 0.85 | NPC1 (0.47) | KMT2AMEN1RAB9ANPC1MAOB | |
| SCHEMBL5068271 | 0.85 | NPC1 (0.47) | KMT2AMEN1RAB9ANPC1MAOB | |
| SCHEMBL5694412 | 0.82 | KMT2A (0.59) | KMT2AMEN1RAB9ANPC1MAOB | |
| SCHEMBL5066623 | 0.76 | RAB9A (0.42) | KMT2AMEN1RAB9ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1653947-A1 | (4-HYDROXYPHENYL)-1H-INDOLE-3-CARBALDEHYDE OXIME DERIVATIVES AS ESTROGENIC AGENTS | Wyeth Holdings Corporation (US) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005018636-A1 | (4-HYDROXYPHENYL)-1H-INDOLE-3-CARBALDEHYDE OXIME DERIVATIVE AS ESTROGENIC AGENTS | WYETH (US) | 2005-03-03 | — | — | WO | disclosed |