Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 13/20 | 0.48 |
| ▸ | LGALS3 | P17931 | 2/20 | 0.46 |
| ▸ | LGALS4 | P56470 | 1/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 3/20 | 0.45 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.45 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.45 |
| ▸ | LGALS9 | O00182 | 1/20 | 0.44 |
| ▸ | LGALS1 | P09382 | 1/20 | 0.44 |
| ▸ | LGALS7; LGALS7B | P47929 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NT5E | P21589 | 1/20 | 0.40 |
| ▸ | SELP | P16109 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5695045 | 1.00 | PTPN1 (0.48) | PTPN1LGALS3LGALS4PTPN2PTPN11 | |
| SCHEMBL5356500 | 1.00 | PTPN1 (0.48) | PTPN1LGALS3LGALS4PTPN2PTPN11 | |
| SCHEMBL5695036 | 1.00 | PTPN1 (0.48) | PTPN1LGALS3LGALS4PTPN2PTPN11 | |
| SCHEMBL5695145 | 1.00 | PTPN1 (0.48) | PTPN1LGALS3LGALS4PTPN2PTPN11 | |
| SCHEMBL5356505 | 1.00 | PTPN1 (0.48) | PTPN1LGALS3LGALS4PTPN2PTPN11 | |
| SCHEMBL16897725 | 0.99 | PTPN1 (0.49) | PTPN1LGALS3LGALS4PTPN2PTPN11 | |
| SCHEMBL13146114 | 0.91 | PTPN1 (0.57) | PTPN1LGALS3LGALS4PTPN2PTPN11 | |
| SCHEMBL22983992 | 0.91 | PTPN1 (0.57) | PTPN1LGALS3LGALS4PTPN2PTPN11 | |
| SCHEMBL22984008 | 0.91 | PTPN1 (0.57) | PTPN1LGALS3LGALS4PTPN2PTPN11 | |
| SCHEMBL5520745 | 0.91 | PTPN1 (0.57) | PTPN1LGALS3LGALS4PTPN2PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1121372-B1 | ADENINE DERIVATIVES | PFIZER LTD (GB) | 2006-06-28 | — | — | EP | disclosed |
| US-6326359-B1 | PURINE DERIVATIVES | PFIZER INC | 2001-12-04 | — | — | US | disclosed |
| EP-1121372-A1 | ADENINE DERIVATIVES | Pfizer Limited (GB) | 2001-08-08 | — | — | EP | disclosed |
| WO-2000023457-A1 | ADENINE DERIVATIVES | PFIZER LIMITED (GB) | 2000-04-27 | — | — | WO | disclosed |