Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.69 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.63 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | MGLL | Q99685 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | GRM5 | P41594 | 1/20 | 0.54 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4003983 | 0.85 | ACHE (0.73) | ACHEEPHX1L3MBTL3L3MBTL1HPGD | |
| SCHEMBL4703329 | 0.84 | KDM4E (0.61) | ACHEEPHX1L3MBTL3L3MBTL1HSD11B1 | |
| SCHEMBL11616794 | 0.83 | ACHE (0.71) | ACHEEPHX1L3MBTL3L3MBTL1HPGD | |
| SCHEMBL10983933 | 0.83 | ACHE (0.71) | ACHEEPHX1L3MBTL3L3MBTL1HPGD | |
| SCHEMBL4003986 | 0.83 | GRM5 (0.73) | ACHEEPHX1L3MBTL3L3MBTL1HPGD | |
| SCHEMBL252026 | 0.82 | HPGD (0.79) | ACHEL3MBTL1HPGDSIGMAR1KMT2A | |
| SCHEMBL7129676 | 0.82 | HPGD (0.79) | ACHEL3MBTL1HPGDSIGMAR1KMT2A | |
| SCHEMBL17875071 | 0.81 | EPHX1 (0.78) | ACHEEPHX1L3MBTL3L3MBTL1HPGD | |
| SCHEMBL6580374 | 0.81 | ACHE (0.69) | ACHEEPHX1L3MBTL3L3MBTL1HPGD | |
| SCHEMBL436168 | 0.81 | ACHE (1.00) | ACHEEPHX1L3MBTL3L3MBTL1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1121372-B1 | ADENINE DERIVATIVES | PFIZER LTD (GB) | 2006-06-28 | — | — | EP | claimed |
| US-6326359-B1 | PURINE DERIVATIVES | PFIZER INC | 2001-12-04 | — | — | US | claimed |
| EP-1121372-A1 | ADENINE DERIVATIVES | Pfizer Limited (GB) | 2001-08-08 | — | — | EP | claimed |
| WO-2000023457-A1 | ADENINE DERIVATIVES | PFIZER LIMITED (GB) | 2000-04-27 | — | — | WO | claimed |
| EP-1121372-B1 | ADENINE DERIVATIVES | PFIZER LTD (GB) | 2006-06-28 | — | — | EP | disclosed |
| US-6326359-B1 | PURINE DERIVATIVES | PFIZER INC | 2001-12-04 | — | — | US | disclosed |
| EP-1121372-A1 | ADENINE DERIVATIVES | Pfizer Limited (GB) | 2001-08-08 | — | — | EP | disclosed |
| WO-2000023457-A1 | ADENINE DERIVATIVES | PFIZER LIMITED (GB) | 2000-04-27 | — | — | WO | disclosed |