Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.75 |
| ▸ | CA2 | P00918 | 2/20 | 0.75 |
| ▸ | POLB | P06746 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | UBE2N | P61088 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.41 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8559503 | 0.86 | CA1 (1.00) | CA1CA2POLBLMNAKMT2A | |
| SCHEMBL7013629 | 0.86 | CA1 (0.69) | CA1CA2POLBLMNAKMT2A | |
| SCHEMBL8561394 | 0.86 | CA1 (0.69) | CA1CA2POLBLMNACRBN | |
| SCHEMBL16865327 | 0.77 | CA1 (0.58) | CA1CA2POLBLMNAMMP2 | |
| SCHEMBL7021931 | 0.77 | CA1 (0.57) | CA1CA2POLBCRBNMMP2 | |
| SCHEMBL13736277 | 0.75 | CA1 (0.44) | CA1CA2POLBLMNAALDH1A1 | |
| SCHEMBL8471820 | 0.75 | CA1 (0.46) | CA1CA2POLBLMNACRBN | |
| SCHEMBL9684862 | 0.70 | CA1 (0.52) | CA1CA2POLBKMT2AMMP2 | |
| SCHEMBL11813074 | 0.70 | POLB (0.70) | CA1CA2POLBLMNAALDH1A1 | |
| SCHEMBL11817179 | 0.70 | POLB (0.64) | CA1CA2POLBLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0949250-A1 | Process for manufacturing alpha1L-adrenoceptor antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1999-10-13 | — | — | EP | claimed |
| EP-0949250-B1 | Process for manufacturing alpha1L-adrenoceptor antagonists | HOFFMANN LA ROCHE (CH) | 2006-05-03 | — | — | EP | disclosed |
| US-6156894-A | INTERMEDIATES | HOFFMAN-LA ROCHE INC. (US) | 2000-12-05 | — | — | US | disclosed |
| EP-0949250-A1 | Process for manufacturing alpha1L-adrenoceptor antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1999-10-13 | — | — | EP | disclosed |