Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 6/20 | 0.75 |
| ▸ | HRH1 | P35367 | 5/20 | 0.75 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.75 |
| ▸ | USP2 | O75604 | 3/20 | 0.75 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.75 |
| ▸ | HRH2 | P25021 | 2/20 | 0.75 |
| ▸ | HTR2A | P28223 | 2/20 | 0.75 |
| ▸ | HTR2B | P41595 | 2/20 | 0.75 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.75 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.75 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.75 |
| ▸ | TEK | Q02763 | 1/20 | 0.75 |
| ▸ | DRD2 | P14416 | 4/20 | 0.65 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.65 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.65 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.65 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.65 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.65 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5182111 | 0.89 | DRD3 (0.80) | DRD3HRH1KCNH2USP2TDP1 | |
| SCHEMBL12288130 | 0.87 | DRD3 (0.77) | DRD3HRH1KCNH2USP2TDP1 | |
| SCHEMBL12288127 | 0.87 | DRD3 (0.77) | DRD3HRH1KCNH2USP2TDP1 | |
| SCHEMBL13035055 | 0.86 | DRD3 (0.83) | DRD3HRH1KCNH2USP2TDP1 | |
| SCHEMBL10063666 | 0.86 | DRD3 (0.83) | DRD3HRH1KCNH2USP2TDP1 | |
| SCHEMBL13949317 | 0.86 | DRD3 (0.83) | DRD3HRH1KCNH2USP2TDP1 | |
| Cetirizine SCHEMBL2455487 | 0.86 | DRD3 (1.00) | DRD3HRH1KCNH2USP2TDP1 | |
| Cetirizine SCHEMBL13724610 | 0.86 | DRD3 (1.00) | DRD3HRH1KCNH2USP2TDP1 | |
| Cetirizine SCHEMBL4176 | 0.86 | DRD3 (1.00) | DRD3HRH1KCNH2USP2TDP1 | |
| Levocetirizine SCHEMBL5935097 | 0.86 | DRD3 (1.00) | DRD3HRH1KCNH2USP2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1222179-B1 | PROCESS FOR PREPARING PIPERAZINE-SUBSTITUTED ALIPHATIC CARBOXYLATES | CAMBREX CHARLES CITY INC (US) | 2006-06-21 | — | — | EP | disclosed |
| EP-1222179-A4 | PROCESS FOR PREPARING PIPERAZINE-SUBSTITUTED ALIPHATIC CARBOXYLATES | SALSBURY CHEMICALS INC (US) | 2003-01-02 | — | — | EP | disclosed |
| EP-1222179-A1 | PROCESS FOR PREPARING PIPERAZINE-SUBSTITUTED ALIPHATIC CARBOXYLATES | Salsbury Chemicals, Inc. (US) | 2002-07-17 | — | — | EP | disclosed |
| US-6239277-B1 | ALKYLATION OF AMINE GROUP IN PIPERAZINE RING | SALSBURY CHEMICALS, INC. | 2001-05-29 | — | — | US | disclosed |
| WO-2001029016-A1 | PROCESS FOR PREPARING PIPERAZINE-SUBSTITUTED ALIPHATIC CARBOXYLATES | SALSBURY CHEMICALS, INC. (US) | 2001-04-26 | — | — | WO | disclosed |