SCHEMBL569633

SCHEMBL569633

C[Si](C)(C)CCOCc1nc2ccccc2[nH]1

nearest known ligand 0.57

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 9/20 0.55
RAB9A P51151 9/20 0.55
SMN1; SMN2 Q16637 7/20 0.55
TP53 P04637 3/20 0.55
TSHR P16473 1/20 0.55
DDAH1 O94760 1/20 0.54
KMT2A Q03164 2/20 0.50
POLB P06746 2/20 0.50
MEN1 O00255 1/20 0.50
LMNA P02545 1/20 0.50
GAA P10253 1/20 0.50
MAPK1 P28482 1/20 0.50
HTT P42858 1/20 0.50
ALDH1A1 P00352 1/20 0.50
TDP1 Q9NUW8 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30648520 1.00 NPC1 (0.55) NPC1RAB9ASMN1; SMN2TP53TSHR
SCHEMBL13572958 0.84 DDAH1 (0.62) NPC1RAB9ASMN1; SMN2TP53TSHR
SCHEMBL711629 0.84 NPC1 (0.69) NPC1RAB9ASMN1; SMN2TP53TSHR
SCHEMBL19540730 0.81 NPC1 (0.58) NPC1RAB9ASMN1; SMN2TP53TSHR
SCHEMBL5864365 0.81 NPC1 (0.58) NPC1RAB9ASMN1; SMN2TP53TSHR
SCHEMBL7836911 0.81 NPC1 (0.35) NPC1RAB9ASMN1; SMN2TP53TSHR
SCHEMBL8278820 0.81 DDAH1 (0.66) NPC1RAB9ASMN1; SMN2TP53TSHR
Hydrochloric Acid SCHEMBL710312 0.80 NPC1 (0.65) NPC1RAB9ASMN1; SMN2TP53TSHR
Hydrochloric Acid SCHEMBL710311 0.80 NPC1 (0.65) NPC1RAB9ASMN1; SMN2TP53TSHR
SCHEMBL31555757 0.78 CYP2C9 (0.46) NPC1RAB9ASMN1; SMN2TP53KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2601192-A1 FUSED HETEROCYCLIC COMPOUNDS Takeda Pharmaceutical Company Limited (JP) 2013-06-12 EP disclosed
WO-2012018909-A1 FUSED HETEROCYCLIC COMPOUNDS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2012-02-09 WO disclosed
EP-1007514-B1 HETEROCYCLIC KETONES AS NPY Y5 ANTAGONISTS BAYER CORP (US) 2006-11-15 EP disclosed
EP-1441725-A1 BENZIMIDAZOLES AND ANALOGUES AND THEIR USE AS PROTEIN KINASES INHIBITORS Aventis Pharmaceuticals Inc. (US) 2004-08-04 EP disclosed
EP-1317445-A2 CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS ANORMED INC. (CA) 2003-06-11 EP disclosed
WO-2003035065-A1 BENZIMIDAZOLES AND ANALOGUES AND THEIR USE AS PROTEIN KINASES INHIBITORS AVENTIS PHARMACEUTICALS INC (US) 2003-05-01 WO disclosed
WO-2002022600-A2 CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS ANORMED INC. (CA) 2002-03-21 WO disclosed
EP-1007514-A1 HETEROCYCLIC KETONES AS NPY Y5 ANTAGONISTS Bayer Corporation (US) 2000-06-14 EP disclosed
WO-1999010330-A1 HETEROCYCLIC KETONES AS NPY Y5 ANTAGONISTS BAYER CORPORATION (US) 1999-03-04 WO disclosed