Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 15/20 | 0.46 |
| ▸ | TGFBR2 | P37173 | 4/20 | 0.46 |
| ▸ | MAP3K20 | Q9NYL2 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | STK4 | Q13043 | 1/20 | 0.35 |
| ▸ | STK3 | Q13188 | 1/20 | 0.35 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.35 |
| ▸ | STK26 | Q9P289 | 1/20 | 0.35 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5696719 | 0.88 | TGFBR1 (0.45) | TGFBR1TGFBR2MAP3K20MAPK14 | |
| SCHEMBL5696812 | 0.85 | TGFBR1 (0.55) | TGFBR1TGFBR2MAP3K20MAPK14 | |
| SCHEMBL5695786 | 0.81 | TGFBR1 (0.46) | TGFBR1TGFBR2MAP3K20MEN1KMT2A | |
| SCHEMBL5695736 | 0.79 | TGFBR1 (0.58) | TGFBR1TGFBR2MAP3K20MEN1KMT2A | |
| SCHEMBL3247927 | 0.77 | TGFBR1 (0.46) | TGFBR1TGFBR2MAP3K20MAPK14 | |
| SCHEMBL3595502 | 0.77 | TGFBR1 (0.41) | TGFBR1TGFBR2MAP3K20MAPK14 | |
| SCHEMBL5138726 | 0.75 | TGFBR1 (0.53) | TGFBR1TGFBR2MAP3K20 | |
| SCHEMBL5138951 | 0.74 | TGFBR1 (0.67) | TGFBR1MAPK14 | |
| SCHEMBL29832794 | 0.73 | TGFBR1 (0.58) | TGFBR1TGFBR2MAPK14NPC1RAB9A | |
| SCHEMBL5139942 | 0.73 | TGFBR1 (0.58) | TGFBR1TGFBR2MAPK14NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656367-A1 | 4- (HETEROCYCLYL- FUSED PHENYL)- 3- (PHENYL OR PYRID -2- YL) PYRAZOLES AS INHIBITORS OF THE ALK-5- RECEPTOR | SmithKline Beecham Corporation (US) | 2006-05-17 | — | — | EP | claimed |
| WO-2004111036-A1 | 4- (HETEROCYCLYL- FUSED PHENYL)- 3- (PHENYL OR PYRID -2- YL) PYRAZOLES AS INHIBITORS OF THE ALK-5- RECEPTOR | SMITHKLINE BEECHAM CORPORATION (US) | 2004-12-23 | — | — | WO | claimed |
| EP-1656367-A1 | 4- (HETEROCYCLYL- FUSED PHENYL)- 3- (PHENYL OR PYRID -2- YL) PYRAZOLES AS INHIBITORS OF THE ALK-5- RECEPTOR | SmithKline Beecham Corporation (US) | 2006-05-17 | — | — | EP | disclosed |
| WO-2004111036-A1 | 4- (HETEROCYCLYL- FUSED PHENYL)- 3- (PHENYL OR PYRID -2- YL) PYRAZOLES AS INHIBITORS OF THE ALK-5- RECEPTOR | SMITHKLINE BEECHAM CORPORATION (US) | 2004-12-23 | — | — | WO | disclosed |