Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.36 |
| ▸ | SRC | P12931 | 3/20 | 0.36 |
| ▸ | QPCT | Q16769 | 1/20 | 0.35 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5697185 | 1.00 | EGFR (0.36) | EGFRERBB2SRCQPCTQPCTL | |
| SCHEMBL4395377 | 0.81 | EGFR (0.57) | EGFRERBB2SRCKCNH2 | |
| SCHEMBL4394667 | 0.81 | EGFR (0.57) | EGFRERBB2SRCKCNH2 | |
| SCHEMBL5473521 | 0.71 | EGFR (0.55) | EGFRERBB2SRCKCNH2 | |
| SCHEMBL5474041 | 0.71 | EGFR (0.55) | EGFRERBB2SRCKCNH2 | |
| SCHEMBL4385173 | 0.69 | ERBB2 (0.53) | EGFRERBB2SRCKCNH2 | |
| SCHEMBL4387569 | 0.69 | ERBB2 (0.53) | EGFRERBB2SRCKCNH2 | |
| SCHEMBL4389707 | 0.68 | ERBB2 (0.74) | EGFRERBB2KCNH2 | |
| SCHEMBL4383098 | 0.68 | ERBB2 (0.74) | EGFRERBB2KCNH2 | |
| SCHEMBL5569332 | 0.66 | EGFR (0.47) | EGFRPIK3CDHCRTR1HCRTR2PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664029-A1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | AstraZeneca AB (SE) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005026152-A1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2005-03-24 | — | — | WO | disclosed |