Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 11/20 | 0.53 |
| ▸ | EGFR | P00533 | 9/20 | 0.53 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.44 |
| ▸ | KDR | P35968 | 3/20 | 0.44 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | GRM5 | P41594 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4385173 | 1.00 | ERBB2 (0.53) | ERBB2EGFRSRCEPHA2KDR | |
| SCHEMBL5474052 | 0.90 | ERBB2 (0.51) | ERBB2EGFRSRCEPHA2KDR | |
| SCHEMBL5479445 | 0.90 | ERBB2 (0.51) | ERBB2EGFRSRCEPHA2KDR | |
| SCHEMBL4394667 | 0.87 | EGFR (0.57) | ERBB2EGFRSRCKCNH2 | |
| SCHEMBL4395377 | 0.87 | EGFR (0.57) | ERBB2EGFRSRCKCNH2 | |
| SCHEMBL4387752 | 0.87 | ERBB2 (0.72) | ERBB2EGFRKCNH2 | |
| SCHEMBL4384932 | 0.87 | ERBB2 (0.72) | ERBB2EGFRKCNH2 | |
| SCHEMBL4390878 | 0.85 | EGFR (0.63) | ERBB2EGFRKCNH2 | |
| SCHEMBL4390260 | 0.85 | EGFR (0.63) | ERBB2EGFRKCNH2 | |
| SCHEMBL4385684 | 0.85 | ERBB2 (0.56) | ERBB2EGFREPHA2KDRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664029-B1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2009-12-02 | — | — | EP | disclosed |