Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 17/20 | 0.51 |
| ▸ | PLA2G10 | O15496 | 5/20 | 0.50 |
| ▸ | PLA2G2F | Q9BZM2 | 3/20 | 0.50 |
| ▸ | PLA2G2E | Q9NZK7 | 3/20 | 0.50 |
| ▸ | PLA2G2D | Q9UNK4 | 3/20 | 0.50 |
| ▸ | PLA2G1B | P04054 | 3/20 | 0.50 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.50 |
| ▸ | PLA2G6 | O60733 | 1/20 | 0.50 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.50 |
| ▸ | PLA2G12B | Q9BX93 | 1/20 | 0.50 |
| ▸ | PLA2G12A | Q9BZM1 | 1/20 | 0.50 |
| ▸ | PLA2G3 | Q9NZ20 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5696951 | 0.90 | PLA2G2A (0.53) | PLA2G2APLA2G10PLA2G2FPLA2G2EPLA2G2D | |
| SCHEMBL5696998 | 0.90 | PLA2G2A (0.61) | PLA2G2APLA2G10PLA2G2FPLA2G2EPLA2G2D | |
| SCHEMBL5697041 | 0.89 | PLA2G2A (0.57) | PLA2G2APLA2G10PLA2G2FPLA2G2EPLA2G2D | |
| SCHEMBL5696972 | 0.88 | PLA2G2A (0.51) | PLA2G2APLA2G10PLA2G2FPLA2G2EPLA2G2D | |
| SCHEMBL5697031 | 0.78 | PLA2G2A (0.66) | PLA2G2APLA2G10PLA2G2FPLA2G2EPLA2G2D | |
| SCHEMBL5697108 | 0.78 | PLA2G2A (0.61) | PLA2G2APLA2G10PLA2G2FPLA2G2EPLA2G2D | |
| SCHEMBL7745703 | 0.78 | PLA2G2A (0.52) | PLA2G2APLA2G10PLA2G2FPLA2G2EPLA2G2D | |
| SCHEMBL5697060 | 0.78 | PLA2G2A (0.46) | PLA2G2APLA2G10PLA2G2FPLA2G2EPLA2G2D | |
| SCHEMBL5697028 | 0.78 | PLA2G2A (0.70) | PLA2G2APLA2G10PLA2G2FPLA2G2EPLA2G2D | |
| SCHEMBL5697018 | 0.76 | PLA2G2A (0.55) | PLA2G2APLA2G10PLA2G2FPLA2G2EPLA2G2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100492-B1 | INDOLE sPLA2 INHIBITORS | LILLY CO ELI (US) | 2006-05-24 | — | — | EP | disclosed |
| US-6451839-B1 | Indole sPLA2 inhibitors | ELI LILLY AND COMPANY | 2002-09-17 | — | — | US | disclosed |