Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPL | P06858 | 1/20 | 0.54 |
| ▸ | LIPC | P11150 | 1/20 | 0.54 |
| ▸ | LIPE | Q05469 | 1/20 | 0.54 |
| ▸ | TRPV1 | Q8NER1 | 9/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3874906 | 0.82 | KDM4E (0.61) | LPLLIPCLIPETRPV1MAPT | |
| SCHEMBL3875037 | 0.73 | KDM4E (0.65) | TRPV1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL7303163 | 0.72 | HDAC3 (0.86) | TRPV1MAPTLMNAMEN1CA1 | |
| SCHEMBL3871686 | 0.71 | GCGR (0.59) | TRPV1MAPTLMNAMEN1KMT2A | |
| SCHEMBL7047919 | 0.70 | LPL (1.00) | LPLLIPCLIPETRPV1MAPT | |
| SCHEMBL1687872 | 0.70 | TRPV1 (0.73) | TRPV1MEN1CA1CA2KMT2A | |
| SCHEMBL1687868 | 0.68 | TRPV1 (0.76) | TRPV1MAPTMEN1CA1CA2 | |
| SCHEMBL13483900 | 0.68 | GAA (0.76) | TRPV1LMNAHDAC3HDAC11HDAC8 | |
| SCHEMBL21652312 | 0.68 | TRPV1 (0.76) | TRPV1MAPTMEN1CA1CA2 | |
| SCHEMBL7301130 | 0.68 | TRPV1 (0.76) | TRPV1MAPTMEN1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673342-A2 | AMIDES THAT INHIBIT VANILLOID RECEPROT SUBTYPE 1 (VR1) RECEPTOR | ABBOTT LABORATORIES (US) | 2006-06-28 | — | — | EP | claimed |
| WO-2005040121-A2 | AMIDES THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | ABBOTT LABORATORIES (US) | 2005-05-06 | — | — | WO | claimed |