Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | IDO1 | P14902 | 2/20 | 0.48 |
| ▸ | AGXT | P21549 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL27454005 | 0.98 | KMT2A (0.47) | KMT2AIDO1AGXTCA2CA9 | |
| SCHEMBL4952656 | 0.89 | CA2 (0.58) | KMT2AAGXTCA2CA9CA1 | |
| SCHEMBL1109812 | 0.83 | KMT2A (0.42) | KMT2AIDO1AGXTCA2CA9 | |
| SCHEMBL19845815 | 0.83 | CA2 (0.52) | KMT2AIDO1AGXTCA2CA9 | |
| SCHEMBL6213294 | 0.83 | CA2 (0.52) | KMT2AIDO1AGXTCA2CA9 | |
| SCHEMBL4662063 | 0.81 | CA2 (0.50) | KMT2ACA2CA9CA1ALDH1A1 | |
| SCHEMBL18030113 | 0.81 | CA2 (0.68) | KMT2AIDO1AGXTCA2CA9 | |
| SCHEMBL6362143 | 0.81 | KMT2A (0.50) | KMT2AIDO1AGXTCA2CA9 | |
| SCHEMBL1284072 | 0.80 | CA1 (0.43) | KMT2ACA2CA9CA1MEN1 | |
| SCHEMBL11027775 | 0.80 | IDO1 (0.55) | KMT2AIDO1CA2CA9CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11718614-B2 | Compounds and methods for treatment of hedgehog pathway associated conditions | SUZHOU MEDNES PHARMA TECH CO., LTD. (CN) | 2023-08-08 | — | — | US | disclosed |
| US-11718614-B2 | Compounds and methods for treatment of hedgehog pathway associated conditions | SUZHOU MEDNES PHARMA TECH CO., LTD. (CN) | 2023-08-08 | — | — | US | disclosed |
| US-20210214353-A1 | COMPOUNDS AND METHODS FOR TREATMENT OF HEDGEHOG PATHWAY ASSOCIATED CONDITIONS | SUZHOU MEDNES PHARMA TECH CO., LTD. (CN) | 2021-07-15 | — | — | US | disclosed |
| WO-2016124139-A1 | HETEROCYCLIC-SUBSTITUTED N-SULFONYLBENZAMIDE DERIVATIVES, PREPARATION METHOD FOR DERIVATIVES, AND PHARMACEUTICAL USE OF DERIVATIVES | 上海海雁医药科技有限公司 | 2016-08-11 | — | — | WO | disclosed |
| EP-1000933-B1 | TRIFLUORO METHYLTHIOMETHYL BENZENE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | IHARA CHEMICAL IND CO (JP) | 2006-08-02 | — | — | EP | disclosed |
| US-6225505-B1 | BY REACTING BENZYL HALIDE DERIVATIVE WITH THIOPHOSGENE AND POTASSIUM FLUORIDE IN ACETONITRILE; HIGH YIELD AND PURITY WITHOUT USING OZONE LAYER-DESTROYING SUBSTANCE; USE AS INTERMEDIATE FOR DRUGS AND AGROCHEMICALS | IHARA CHEMICAL INDUSTRY CO., LTD (JP) | 2001-05-01 | — | — | US | disclosed |
| EP-1000933-A1 | TRIFLUORO METHYLTHIOMETHYL BENZENE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | Ihara Chemical Industry Co., Ltd. (JP) | 2000-05-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11718614-B2 | Compounds and methods for treatment of hedgehog pathway associated conditions | SHH, GLI1, SMO | KMT2A 4325/4885IDO1 3862/4885AGXT 2280/4885 |
| US-20210214353-A1 | COMPOUNDS AND METHODS FOR TREATMENT OF HEDGEHOG PATHWAY ASSOCIATED CONDITIONS | SHH, GLI1, SMO | KMT2A 4325/4885IDO1 3862/4885AGXT 2280/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.