Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.46 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27899079 | 0.85 | SMN1; SMN2 (0.60) | HRH3SMN1; SMN2MEN1NPC1TP53 | |
| SCHEMBL5697707 | 0.84 | HRH3 (0.67) | HRH3SMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL392531 | 0.80 | HRH3 (0.61) | HRH3SMN1; SMN2HIF1AEPAS1MEN1 | |
| SCHEMBL15467001 | 0.78 | HRH3 (0.87) | HRH3SMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL1820767 | 0.78 | HRH3 (0.58) | HRH3SMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL1865018 | 0.77 | HRH3 (0.85) | HRH3 | |
| SCHEMBL23235216 | 0.76 | HRH3 (0.56) | HRH3SMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL115530 | 0.76 | DRD2 (0.56) | HRH3SMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL1822660 | 0.76 | HRH3 (0.56) | HRH3SMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL1820769 | 0.76 | HRH3 (0.56) | HRH3SMN1; SMN2ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1667990-A2 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2006-06-14 | — | — | EP | claimed |
| WO-2005027823-A2 | 3-HETEROCYCLYL-INDOLE DERIVATIVES AS INHIBITORS OF GLYCOGEN SYNTHASE KINASE-3 (GSK-3) | ASTRAZENECA AB (SE) | 2005-03-31 | — | — | WO | claimed |
| EP-1667990-A2 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005027823-A2 | 3-HETEROCYCLYL-INDOLE DERIVATIVES AS INHIBITORS OF GLYCOGEN SYNTHASE KINASE-3 (GSK-3) | ASTRAZENECA AB (SE) | 2005-03-31 | — | — | WO | disclosed |