Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 5/20 | 0.43 |
| ▸ | KCNA3 | P22001 | 2/20 | 0.43 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5697859 | 0.91 | HTT (0.52) | PKMHTTKCNA5KCNA3KCNK3 | |
| SCHEMBL5697905 | 0.90 | KCNA5 (0.49) | PKMHTTKCNA5KCNA3KCNK3 | |
| SCHEMBL5697880 | 0.87 | SGMS1 (0.47) | ALDH1A1HTTKCNA5POLB | |
| SCHEMBL2208909 | 0.85 | KCNA5 (0.56) | ALDH1A1PKMHTTKCNA5KCNA3 | |
| SCHEMBL5697846 | 0.82 | KCNA5 (0.56) | ALDH1A1PKMKCNA5POLB | |
| SCHEMBL5697849 | 0.82 | POLB (0.48) | ALDH1A1HTTKCNA5SMN1; SMN2POLB | |
| SCHEMBL5697847 | 0.81 | TAS1R3 (0.52) | ALDH1A1PKMHTTKCNA5KCNA3 | |
| SCHEMBL5697921 | 0.77 | KCNA5 (0.66) | ALDH1A1HTTKCNA5KCNA3KCNK3 | |
| SCHEMBL2209930 | 0.77 | HTT (0.59) | PKMHTTKCNA5KCNA3KCNK3 | |
| SCHEMBL5697895 | 0.77 | KCNA5 (0.49) | ALDH1A1KCNA5NPC1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1222163-B1 | 2'-SUBSTITUTED 1,1'-BIPHENYL-2-CARBONAMIDES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS A MEDICAMENT AND PHARMACEUTICAL PREPARATIONS CONTAINING SAID COMPOUNDS | SANOFI AVENTIS DEUTSCHLAND (DE) | 2006-07-12 | — | — | EP | disclosed |
| EP-1222163-A1 | 2'-SUBSTITUTED 1,1'-BIPHENYL-2-CARBONAMIDES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS A MEDICAMENT AND PHARMACEUTICAL PREPARATIONS CONTAINING SAID COMPOUNDS | Aventis Pharma Deutschland GmbH (DE) | 2002-07-17 | — | — | EP | disclosed |
| WO-2001025189-A1 | 2'-SUBSTITUTED 1,1'-BIPHENYL-2-CARBONAMIDES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS A MEDICAMENT AND PHARMACEUTICAL PREPARATIONS CONTAINING SAID COMPOUNDS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-04-12 | — | — | WO | disclosed |