Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 1/20 | 0.62 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.62 |
| ▸ | KDR | P35968 | 13/20 | 0.54 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzene SCHEMBL27839441 | 0.90 | MAPK9 (0.54) | MAPK9MAPK10KDRP2RX4FLT1 | |
| SCHEMBL528245 | 0.90 | MAPK9 (0.54) | MAPK9MAPK10KDRP2RX4FLT1 | |
| SCHEMBL19219071 | 0.89 | MAPK9 (0.63) | MAPK9MAPK10KDRNOTUMMAPKAPK2 | |
| Hydrochloric Acid SCHEMBL27683877 | 0.89 | MAPK9 (0.53) | MAPK9MAPK10KDRP2RX4FLT1 | |
| SCHEMBL11395368 | 0.84 | MAPK9 (0.54) | MAPK9MAPK10KDRMAPKAPK2P2RX4 | |
| Pyridine SCHEMBL14877258 | 0.84 | MAPK9 (0.54) | MAPK9MAPK10KDRMAPKAPK2MAPT | |
| SCHEMBL26562756 | 0.84 | KDR (0.55) | MAPK9MAPK10KDRMAPTP2RX4 | |
| SCHEMBL15987568 | 0.82 | MAPK9 (0.48) | MAPK9MAPK10KDRP2RX4FLT1 | |
| SCHEMBL13772768 | 0.82 | MAPK9 (0.51) | MAPK9MAPK10KDRP2RX4FLT1 | |
| SCHEMBL20918400 | 0.82 | MAPK9 (0.51) | MAPK9MAPK10KDRMAPTP2RX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1255406-C | Substituted 2-acyl-3-(heteroaryl)-imidazo [1,2-a] pyrimidines, and related pharmaceutical compoistions and methods | ORTHO MCNEIL PHARM INC (US) | 2006-05-10 | — | — | CN | claimed |
| CN-1342162-A | Substituted 2-acyl-3-(heteroaryl)-imidazo [1,2-a] pyrimidines, and related pharmaceutical compoistions and methods | ORTHO MCNEIL PHARM INC (US) | 2002-03-27 | — | — | CN | claimed |
| EP-1682143-A2 | COMBINATIONS COMPRISING AN HSP90 INHIBITOR AND A PHOPHODIESTERASE INHIBITOR FOR TREATING OR PREVENTING NEOPLASIA | Pharmacia Corporation (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005044194-A2 | TREATMENT OR PREVENTION OF NEOPLASIA BY USE OF AN Hsp90 INHIBITOR | PHARMACIA CORPORATION (US) | 2005-05-19 | — | — | WO | disclosed |
| WO-2005041879-A2 | COMBINATIONS COMPRISING AN Hsp90 INHIBITOR AND A PHOPHODIESTERASE INHIBITOR FOR TREATING OR PREVENTING NEOPLASIA | PHARMACIA CORPORATION (US) | 2005-05-12 | — | — | WO | disclosed |