Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | LTA4H | P09960 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5698662 | 1.00 | KMT2A (0.55) | KMT2APOLBMEN1LTA4HALDH1A1 | |
| SCHEMBL5698644 | 0.84 | CYP19A1 (0.59) | KMT2APOLBMEN1ALDH1A1HTT | |
| SCHEMBL5698641 | 0.84 | CYP19A1 (0.59) | KMT2APOLBMEN1ALDH1A1HTT | |
| SCHEMBL31406720 | 0.82 | CYP19A1 (0.46) | KMT2AMEN1ALDH1A1MAPTAKR1C1 | |
| SCHEMBL6934616 | 0.81 | ALDH1A1 (0.67) | KMT2APOLBMEN1LTA4HALDH1A1 | |
| SCHEMBL6934618 | 0.81 | ALDH1A1 (0.67) | KMT2APOLBMEN1LTA4HALDH1A1 | |
| SCHEMBL12485905 | 0.79 | MEN1 (0.81) | KMT2APOLBMEN1ALDH1A1HTT | |
| SCHEMBL12485904 | 0.79 | MEN1 (0.81) | KMT2APOLBMEN1ALDH1A1HTT | |
| SCHEMBL11219395 | 0.79 | AKR1C1 (0.73) | KMT2APOLBMEN1ALDH1A1HTT | |
| SCHEMBL11219398 | 0.79 | AKR1C1 (0.73) | KMT2APOLBMEN1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682143-A2 | COMBINATIONS COMPRISING AN HSP90 INHIBITOR AND A PHOPHODIESTERASE INHIBITOR FOR TREATING OR PREVENTING NEOPLASIA | Pharmacia Corporation (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005044194-A2 | TREATMENT OR PREVENTION OF NEOPLASIA BY USE OF AN Hsp90 INHIBITOR | PHARMACIA CORPORATION (US) | 2005-05-19 | — | — | WO | disclosed |
| WO-2005041879-A2 | COMBINATIONS COMPRISING AN Hsp90 INHIBITOR AND A PHOPHODIESTERASE INHIBITOR FOR TREATING OR PREVENTING NEOPLASIA | PHARMACIA CORPORATION (US) | 2005-05-12 | — | — | WO | disclosed |