SCHEMBL5698697

SCHEMBL5698697

NS(=O)(=O)c1ccc(-n2nc(-c3ccc(Cl)cc3)cc2-c2ccc(Cl)cc2)cc1

nearest known ligand 0.88

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 13/20 0.88
PTGS1 P23219 3/20 0.82
PDPK1 O15530 1/20 0.70
CYP2C9 P11712 1/20 0.70
CHRNA7 P36544 3/20 0.68
SMN1; SMN2 Q16637 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8112204 0.95 PTGS2 (0.80) PTGS2PTGS1PDPK1CYP2C9CHRNA7
SCHEMBL8112778 0.95 PTGS2 (0.80) PTGS2PTGS1PDPK1CYP2C9CHRNA7
SCHEMBL212707 0.95 PTGS2 (0.80) PTGS2PTGS1PDPK1CYP2C9CHRNA7
SCHEMBL212983 0.94 PTGS2 (0.83) PTGS2PTGS1PDPK1CYP2C9CHRNA7
SCHEMBL8114069 0.94 PTGS2 (0.79) PTGS2PTGS1PDPK1CYP2C9CHRNA7
SCHEMBL8119659 0.94 PTGS2 (0.79) PTGS2PTGS1PDPK1CYP2C9CHRNA7
SCHEMBL8111712 0.94 PTGS2 (0.79) PTGS2PTGS1PDPK1CYP2C9
SCHEMBL6906481 0.94 PTGS2 (0.79) PTGS2PTGS1PDPK1CYP2C9CHRNA7
SCHEMBL8112050 0.94 PTGS2 (0.79) PTGS2PTGS1PDPK1CYP2C9CHRNA7
SCHEMBL8121503 0.94 PTGS2 (0.83) PTGS2PTGS1PDPK1CYP2C9CHRNA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0731796-B1 1,3,5-TRISUBSTITUTED PYRAZOLE COMPOUNDS FOR TREATMENT OF INFLAMMATION SEARLE & CO (US) 2000-08-02 EP claimed
EP-1682143-A2 COMBINATIONS COMPRISING AN HSP90 INHIBITOR AND A PHOPHODIESTERASE INHIBITOR FOR TREATING OR PREVENTING NEOPLASIA Pharmacia Corporation (US) 2006-07-26 EP disclosed
WO-2005044194-A2 TREATMENT OR PREVENTION OF NEOPLASIA BY USE OF AN Hsp90 INHIBITOR PHARMACIA CORPORATION (US) 2005-05-19 WO disclosed
WO-2005041879-A2 COMBINATIONS COMPRISING AN Hsp90 INHIBITOR AND A PHOPHODIESTERASE INHIBITOR FOR TREATING OR PREVENTING NEOPLASIA PHARMACIA CORPORATION (US) 2005-05-12 WO disclosed
EP-0731796-B1 1,3,5-TRISUBSTITUTED PYRAZOLE COMPOUNDS FOR TREATMENT OF INFLAMMATION SEARLE & CO (US) 2000-08-02 EP disclosed
EP-0731796-A1 1,3,5-TRISUBSTITUTED PYRAZOLE COMPOUNDS FOR TREATMENT OF INFLAMMATION G.D. SEARLE & CO. (US) 1996-09-18 EP disclosed
US-5434178-A 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation G.D. SEARLE & CO. (US) 1995-07-18 US disclosed
WO-1995015318-A1 1,3,5-TRISUBSTITUTED PYRAZOLE COMPOUNDS FOR TREATMENT OF INFLAMMATION G.D. SEARLE & CO. (US) 1995-06-08 WO disclosed