Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.57 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.50 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.50 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | PPARD | Q03181 | 1/20 | 0.48 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.48 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.48 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.47 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.45 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9397701 | 1.00 | CA2 (0.57) | CA2GPR84GRIK1GRIK2FFAR1 | |
| SCHEMBL13539144 | 1.00 | CA2 (0.57) | CA2GPR84GRIK1GRIK2FFAR1 | |
| SCHEMBL8324700 | 1.00 | CA2 (0.57) | CA2GPR84GRIK1GRIK2FFAR1 | |
| SCHEMBL10964151 | 1.00 | CA2 (0.57) | CA2GPR84GRIK1GRIK2FFAR1 | |
| SCHEMBL22612259 | 1.00 | CA2 (0.57) | CA2GPR84GRIK1GRIK2FFAR1 | |
| SCHEMBL8319690 | 1.00 | CA2 (0.57) | CA2GPR84GRIK1GRIK2FFAR1 | |
| SCHEMBL7515977 | 0.98 | CA2 (0.61) | CA2GPR84GRIK1GRIK2FFAR1 | |
| SCHEMBL1649191 | 0.98 | CA2 (0.61) | CA2GPR84GRIK1GRIK2FFAR1 | |
| SCHEMBL22612320 | 0.98 | CA2 (0.61) | CA2GPR84GRIK1GRIK2FFAR1 | |
| SCHEMBL9092793 | 0.98 | CA2 (0.54) | CA2GPR84GRIK1GRIK2FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0569482-B1 | SYNTHESIS OF INTERMEDIATES IN THE PREPARATION OF ACAT INHIBITORS | PFIZER (US) | 1995-08-02 | — | — | EP | claimed |
| EP-1285652-B1 | Novel fatty acid analogues for the treatment of hypertension | THIA MEDICA AS (NO) | 2006-08-16 | — | — | EP | disclosed |
| EP-1284139-B1 | Novel fatty acid analogues for the treatment of fatty liver | THIA MEDICA AS (NO) | 2006-08-02 | — | — | EP | disclosed |
| EP-1075260-B1 | NOVEL FATTY ACID ANALOGUES FOR THE TREATMENT OF SECONDARY RESTENOSIS | THIA MEDICA AS (NO) | 2005-10-19 | — | — | EP | disclosed |
| EP-1075258-B1 | NOVEL FATTY ANALOGUES FOR THE TREATMENT OF OBESITY | THIA MEDICA AS (NO) | 2003-08-20 | — | — | EP | disclosed |
| EP-1075259-B1 | NOVEL FATTY ANALOGUES FOR THE TREATMENT OF DIABETES | THIA MEDICA AS (NO) | 2003-07-23 | — | — | EP | disclosed |
| EP-0609960-B1 | New N-heteroarylamide derivatives as inhibitors of acyl coenzyme A: cholestrol acyl transferase | PFIZER (US) | 1999-03-03 | — | — | EP | disclosed |
| US-5656634-A | N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1997-08-12 | — | — | US | disclosed |
| EP-0418071-B1 | New N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase | PFIZER (US) | 1995-04-26 | — | — | EP | disclosed |
| US-5362878-A | Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1994-11-08 | — | — | US | disclosed |
| EP-0609960-A1 | New N-heteroarylamide derivatives as inhibitors of acyl coenzyme A: cholestrol acyl transferase | PFIZER INC. (US) | 1994-08-10 | — | — | EP | disclosed |
| WO-1992013843-A1 | SYNTHESIS OF INTERMEDIATES IN THE PREPARATION OF ACAT INHIBITORS | PFIZER INC. (US) | 1992-08-20 | — | — | WO | disclosed |
| WO-1991004027-A1 | NEW N-ARYL AND N-HETEROARYLAMIDE AND UREA DERIVATIVES AS INHIBITORS OF ACYL COENZYME A: CHOLESTEROL ACYL TRANSFERASE (ACAT) | PFIZER INC. (US) | 1991-04-04 | — | — | WO | disclosed |
| EP-0418071-A2 | New N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase | PFIZER INC. (US) | 1991-03-20 | — | — | EP | disclosed |
| US-4459158-A | THIOALKANOIC ACID DERIVATIVES | PHILLIPS PETROLEUM COMPANY (US) | 1984-07-10 | — | — | US | disclosed |