Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 14/20 | 0.54 |
| ▸ | DRD3 | P35462 | 14/20 | 0.54 |
| ▸ | DRD4 | P21917 | 13/20 | 0.49 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 7/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 7/20 | 0.45 |
| ▸ | CHRM5 | P08912 | 7/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 7/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3291917 | 1.00 | DRD2 (0.54) | DRD2DRD3DRD4GRIN1GRIN2B | |
| Trifluoroacetic Acid SCHEMBL3290922 | 0.92 | DRD2 (0.54) | DRD2DRD3DRD4GRIN1GRIN2B | |
| Trifluoroacetic Acid SCHEMBL5699575 | 0.92 | DRD2 (0.54) | DRD2DRD3DRD4GRIN1GRIN2B | |
| Trifluoroacetic Acid SCHEMBL3289427 | 0.90 | DRD2 (0.51) | DRD2DRD3DRD4GRIN1GRIN2B | |
| Trifluoroacetic Acid SCHEMBL5699539 | 0.90 | DRD2 (0.51) | DRD2DRD3DRD4GRIN1GRIN2B | |
| Trifluoroacetic Acid SCHEMBL3290463 | 0.90 | DRD2 (0.57) | DRD2DRD3DRD4GRIN1GRIN2B | |
| Trifluoroacetic Acid SCHEMBL5699583 | 0.90 | DRD2 (0.57) | DRD2DRD3DRD4GRIN1GRIN2B | |
| Trifluoroacetic Acid SCHEMBL3289469 | 0.90 | DRD2 (0.51) | DRD2DRD3DRD4GRIN1GRIN2B | |
| Trifluoroacetic Acid SCHEMBL3295580 | 0.90 | DRD2 (0.50) | DRD2DRD3DRD4GRIN1GRIN2B | |
| Trifluoroacetic Acid SCHEMBL5699596 | 0.90 | DRD2 (0.50) | DRD2DRD3DRD4GRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692129-A1 | KETO LACTAM COMPOUNDS AND USE THEREOF | Abbott GmbH & Co. KG (DE) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005056546-A1 | KETO LACTAM COMPOUNDS AND USE THEREOF | ABBOTT GMBH & CO. KG (DE) | 2005-06-23 | — | — | WO | disclosed |