Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGA4 | P13612 | 9/20 | 0.52 |
| ▸ | ITGB1 | P05556 | 8/20 | 0.52 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | JAK1 | P23458 | 2/20 | 0.46 |
| ▸ | TYK2 | P29597 | 2/20 | 0.46 |
| ▸ | JAK3 | P52333 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.46 |
| ▸ | WNT3A | P56704 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5701009 | 0.91 | ITGA4 (0.59) | ITGA4ITGB1MEN1KMT2ACHEK1 | |
| SCHEMBL5700890 | 0.86 | ITGA4 (0.57) | ITGA4ITGB1MEN1KMT2APOLB | |
| SCHEMBL7587157 | 0.77 | ITGB1 (0.61) | ITGA4ITGB1 | |
| SCHEMBL7587137 | 0.77 | ITGB1 (0.61) | ITGA4ITGB1 | |
| SCHEMBL7429626 | 0.77 | ITGB1 (0.59) | ITGA4ITGB1MEN1KMT2ACHEK1 | |
| SCHEMBL7561313 | 0.77 | ITGB1 (0.63) | ITGA4ITGB1CHEK1MAPT | |
| SCHEMBL5701006 | 0.76 | ITGA4 (0.61) | ITGA4ITGB1MEN1KMT2APOLB | |
| SCHEMBL7387358 | 0.76 | ITGA4 (0.62) | ITGA4ITGB1MEN1KMT2ACHEK1 | |
| SCHEMBL5701001 | 0.76 | ITGB1 (0.72) | ITGA4ITGB1MEN1KMT2A | |
| SCHEMBL5701018 | 0.76 | ITGB1 (0.65) | ITGA4ITGB1MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1027328-B1 | SUBSTITUTED ANILIDES | AVENTIS PHARMA LTD (GB) | 2006-08-23 | — | — | EP | disclosed |
| US-6479519-B1 | INHIBITORS OF CELL ADHESION; TREATMENT OF ASTHMA OR INFLAMMATORY BOWEL DISEASE | AVENTIS PHARMA LIMITED (GB) | 2002-11-12 | — | — | US | disclosed |
| EP-1027328-A1 | SUBSTITUTED ANILIDES | Aventis Pharma Limited (GB) | 2000-08-16 | — | — | EP | disclosed |
| WO-1999023063-A1 | SUBSTITUTED ANILIDES | AVENTIS PHARMA LIMITED (GB) | 1999-05-14 | — | — | WO | disclosed |