Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | PRKCA | P17252 | 3/20 | 0.59 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.59 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.59 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.59 |
| ▸ | PAM | P19021 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.52 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.52 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nonanoate SCHEMBL30443683 | 0.97 | LMNA (0.64) | LMNAALDH1A1MAPTPRKCAPRKCE | |
| Decanoic Acid SCHEMBL1707865 | 0.97 | LMNA (0.64) | LMNAALDH1A1MAPTPRKCAPRKCE | |
| SCHEMBL6687221 | 0.94 | LMNA (0.72) | LMNAALDH1A1MAPTPRKCAPRKCE | |
| SCHEMBL889430 | 0.94 | LMNA (0.72) | LMNAALDH1A1MAPTPRKCAPRKCE | |
| SCHEMBL16584788 | 0.94 | LMNA (0.72) | LMNAALDH1A1MAPTPRKCAPRKCE | |
| SCHEMBL20272112 | 0.94 | LMNA (0.72) | LMNAALDH1A1MAPTPRKCAPRKCE | |
| SCHEMBL14788739 | 0.94 | LMNA (0.72) | LMNAALDH1A1MAPTPRKCAPRKCE | |
| SCHEMBL14553744 | 0.94 | LMNA (0.72) | LMNAALDH1A1MAPTPRKCAPRKCE | |
| SCHEMBL8394438 | 0.94 | LMNA (0.72) | LMNAALDH1A1MAPTPRKCAPRKCE | |
| SCHEMBL141959 | 0.94 | LMNA (0.72) | LMNAALDH1A1MAPTPRKCAPRKCE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006127831-A1 | MISCIBLE HIGH TG POLYESTER/POLYMER BLEND COMPOSITIONS AND FILMS FORMED THEREFROM | EASTMAN CHEMICAL COMPANY (US) | 2006-11-30 | — | — | WO | disclosed |
| EP-1697462-A1 | POLYMER BLENDS WITH IMPROVED RHEOLOGY AND IMPROVED UNNOTCHED IMPACT STRENGTH | EASTMAN CHEMICAL COMPANY (US) | 2006-09-06 | — | — | EP | disclosed |
| EP-1697452-A1 | POLYESTER COMPOSITIONS | EASTMAN CHEMICAL COMPANY (US) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005063883-A1 | POLYMER BLENDS WITH IMPROVED RHEOLOGY AND IMPROVED UNNOTCHED IMPACT STRENGTH | EASTMAN CHEMICAL COMPANY (US) | 2005-07-14 | — | — | WO | disclosed |
| WO-2005063868-A1 | POLYESTER COMPOSITIONS | EASTMAN CHEMICAL COMPANY (US) | 2005-07-14 | — | — | WO | disclosed |