Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 3/20 | 0.79 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.77 |
| ▸ | RET | P07949 | 2/20 | 0.76 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.76 |
| ▸ | KIT | P10721 | 2/20 | 0.68 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.68 |
| ▸ | FLT3 | P36888 | 1/20 | 0.59 |
| ▸ | PLK4 | O00444 | 1/20 | 0.59 |
| ▸ | PLK1 | P53350 | 1/20 | 0.59 |
| ▸ | KDR | P35968 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | APP | P05067 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | SNCA | P37840 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | CTRC | Q99895 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20399720 | 1.00 | ERBB2 (0.79) | ERBB2PDGFRBRETFGFR1KIT | |
| SCHEMBL14519135 | 0.90 | ERBB2 (0.97) | ERBB2PDGFRBRETFGFR1KIT | |
| SCHEMBL6001567 | 0.90 | ERBB2 (0.97) | ERBB2PDGFRBRETFGFR1KIT | |
| SCHEMBL6001605 | 0.88 | ERBB2 (1.00) | ERBB2PDGFRBRETFGFR1KIT | |
| SCHEMBL1452716 | 0.87 | PDGFRB (1.00) | ERBB2PDGFRBRETFGFR1KIT | |
| SCHEMBL1452713 | 0.87 | PDGFRB (1.00) | ERBB2PDGFRBRETFGFR1KIT | |
| SCHEMBL4624850 | 0.86 | PDGFRB (1.00) | ERBB2PDGFRBRETFGFR1KIT | |
| SCHEMBL141892 | 0.86 | PDGFRB (1.00) | ERBB2PDGFRBRETFGFR1KIT | |
| SCHEMBL20898243 | 0.86 | PDGFRB (1.00) | ERBB2PDGFRBRETFGFR1KIT | |
| SCHEMBL29496459 | 0.86 | PDGFRB (1.00) | ERBB2PDGFRBRETFGFR1KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1696906-A1 | NOVEL THERAPEUTIC USE OF INDOLINONE DERIVATIVES | Leo Pharma A/S (DK) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005058309-A1 | NOVEL THERAPEUTIC USE OF INDOLINONE DERIVATIVES | LEO PHARMA A/S (DK) | 2005-06-30 | — | — | WO | disclosed |