Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 8/20 | 1.00 |
| ▸ | ERBB2 | P04626 | 3/20 | 1.00 |
| ▸ | RET | P07949 | 3/20 | 1.00 |
| ▸ | FGFR1 | P11362 | 1/20 | 1.00 |
| ▸ | KIT | P10721 | 2/20 | 0.70 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.70 |
| ▸ | IGF1R | P08069 | 2/20 | 0.70 |
| ▸ | FLT3 | P36888 | 1/20 | 0.58 |
| ▸ | PLK4 | O00444 | 1/20 | 0.58 |
| ▸ | PLK1 | P53350 | 1/20 | 0.58 |
| ▸ | KDR | P35968 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | APP | P05067 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | SNCA | P37840 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | CTRC | Q99895 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20898243 | 1.00 | PDGFRB (1.00) | PDGFRBERBB2RETFGFR1KIT | |
| SCHEMBL29496459 | 1.00 | PDGFRB (1.00) | PDGFRBERBB2RETFGFR1KIT | |
| SCHEMBL141892 | 1.00 | PDGFRB (1.00) | PDGFRBERBB2RETFGFR1KIT | |
| SCHEMBL14519135 | 0.88 | ERBB2 (0.97) | PDGFRBERBB2RETFGFR1KIT | |
| SCHEMBL6001567 | 0.88 | ERBB2 (0.97) | PDGFRBERBB2RETFGFR1KIT | |
| SCHEMBL6001605 | 0.87 | ERBB2 (1.00) | PDGFRBERBB2RETFGFR1KIT | |
| SCHEMBL20399720 | 0.86 | ERBB2 (0.79) | PDGFRBERBB2RETFGFR1KIT | |
| SCHEMBL1452716 | 0.86 | PDGFRB (1.00) | PDGFRBERBB2RETFGFR1KIT | |
| SCHEMBL1452713 | 0.86 | PDGFRB (1.00) | PDGFRBERBB2RETFGFR1KIT | |
| SCHEMBL5702159 | 0.86 | ERBB2 (0.79) | PDGFRBERBB2RETFGFR1KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1372621-B1 | NOVEL USE OF TYROSINE KINASE FRK INHIBITOR | INNOVENTUS PROJECT AB (SE) | 2008-06-11 | — | — | EP | claimed |
| US-20070167488-A1 | Novel therapeutic use | LEO PHARMA A/S (DK) | 2007-07-19 | — | — | US | claimed |
| EP-1696906-A1 | NOVEL THERAPEUTIC USE OF INDOLINONE DERIVATIVES | Leo Pharma A/S (DK) | 2006-09-06 | — | — | EP | claimed |
| WO-2005058309-A1 | NOVEL THERAPEUTIC USE OF INDOLINONE DERIVATIVES | LEO PHARMA A/S (DK) | 2005-06-30 | — | — | WO | claimed |
| WO-2005044181-A2 | PROTECTION OF TISSUES AND CELLS FROM CYTOTOXIC EFFECTS OF IONIZING RADIATION BY ABL INHIBITORS | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2005-05-19 | — | — | WO | claimed |
| EP-0931152-A2 | CRYSTAL STRUCTURES OF A PROTEIN TYROSINE KINASE | Sugen, Inc. (US) | 1999-07-28 | — | — | EP | claimed |
| WO-1998007835-A9 | CRYSTAL STRUCTURES OF A PROTEIN TYROSINE KINASE | — | 1998-06-11 | — | — | WO | claimed |
| WO-1998007835-A2 | CRYSTAL STRUCTURES OF A PROTEIN TYROSINE KINASE | SUGEN, INC. (US) | 1998-02-26 | — | — | WO | claimed |
| US-11998545-B2 | Substituted pyrazolo[1,5-a]pyridine compounds as RET kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2024-06-04 | — | — | US | disclosed |
| US-20240066029-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2024-02-29 | — | — | US | disclosed |
| CN-116963718-A | Composition for ophthalmic care | 瑞比奥科技公司 | 2023-10-27 | — | — | CN | disclosed |
| CN-116917464-A | Platelet alpha particles for delivery of multiple proteins | 希思特思医疗保健公司 | 2023-10-20 | — | — | CN | disclosed |
| US-11648243-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2023-05-16 | — | — | US | disclosed |
| US-20230090520-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2023-03-23 | — | — | US | disclosed |
| US-20030069421-A1 | 3-(Piperazinylbenzylidenyl)-2-indolinone compounds and derivatives as protein tyrosine kinase inhibitors | SUGEN, INC. | 2003-04-10 | — | — | US | disclosed |
| US-6486185-B1 | 3-heteroarylidene-2-indolinone protein kinase inhibitors | SUGEN, INC. | 2002-11-26 | — | — | US | disclosed |
| EP-0934931-A2 | 3-Benzylidene-2-indolinones and their analogues as tyrosine kinase activity modulators | Sugen, Inc. (US) | 1999-08-11 | — | — | EP | disclosed |
| EP-0931152-A2 | CRYSTAL STRUCTURES OF A PROTEIN TYROSINE KINASE | Sugen, Inc. (US) | 1999-07-28 | — | — | EP | disclosed |
| WO-1998007835-A9 | CRYSTAL STRUCTURES OF A PROTEIN TYROSINE KINASE | — | 1998-06-11 | — | — | WO | disclosed |
| WO-1998007835-A2 | CRYSTAL STRUCTURES OF A PROTEIN TYROSINE KINASE | SUGEN, INC. (US) | 1998-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11648243-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | RET, BRAF, RAF1 | PDGFRB 2138/4885ERBB2 491/4885RET 1/4885 |
| US-20030069421-A1 | 3-(Piperazinylbenzylidenyl)-2-indolinone compounds and derivatives as protein tyrosine kinase inhibitors | ABL1, ERBB2, PTK2B | PDGFRB 280/4885ERBB2 2/4885RET 44/4885 |
| US-20070167488-A1 | Novel therapeutic use | MAG, PMP22, MYT1 | PDGFRB 4421/4885ERBB2 4314/4885RET 3720/4885 |
| US-11998545-B2 | Substituted pyrazolo[1,5-a]pyridine compounds as RET kinase inhibitors | RET, ROR1, BRAF | PDGFRB 1563/4885ERBB2 135/4885RET 1/4885 |
| US-20230090520-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | RET, ROR1, BRAF | PDGFRB 1563/4885ERBB2 135/4885RET 1/4885 |
| US-20240066029-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | RET, ROR1, BRAF | PDGFRB 1563/4885ERBB2 135/4885RET 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.