Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bvt.115959. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A known ✓ | P29274 | 11/20 | 0.80 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.84 |
| ▸ | ADORA2B | P29275 | 10/20 | 0.80 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3749410 | 0.92 | ADORA3 (1.00) | ADORA3ADORA2AADORA2B | |
| SCHEMBL3749420 | 0.92 | ADORA3 (1.00) | ADORA3ADORA2AADORA2B | |
| SCHEMBL13863566 | 0.92 | ADORA3 (1.00) | ADORA3ADORA2AADORA2B | |
| Bvt.115959 SCHEMBL12012980 | 0.90 | ADORA2A (1.00) | ADORA3ADORA2AADORA2BADORA1 | |
| Bvt.115959 SCHEMBL13224527 | 0.90 | ADORA2A (1.00) | ADORA3ADORA2AADORA2BADORA1 | |
| Bvt.115959 SCHEMBL24838605 | 0.90 | ADORA2A (1.00) | ADORA3ADORA2AADORA2BADORA1 | |
| Bvt.115959 SCHEMBL990077 | 0.90 | ADORA2A (1.00) | ADORA3ADORA2AADORA2BADORA1 | |
| Bvt.115959 SCHEMBL13224547 | 0.90 | ADORA2A (1.00) | ADORA3ADORA2AADORA2BADORA1 | |
| Bvt.115959 SCHEMBL13863558 | 0.90 | ADORA2A (1.00) | ADORA3ADORA2AADORA2BADORA1 | |
| Bvt.115959 SCHEMBL990075 | 0.90 | ADORA2A (1.00) | ADORA3ADORA2AADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697393-A1 | IMPROVED SYNTHESIS OF 2-SUBSTITUTED ADENOSINES | BIOVITRUM AB (SE) | 2006-09-06 | — | — | EP | disclosed |
| EP-1694691-A1 | IMPROVED SYNTHESIS OF 2-SUBSTITUTED ADENOSINES | BIOVITRUM AB (SE) | 2006-08-30 | — | — | EP | disclosed |
| WO-2005056571-A1 | IMPROVED SYNTHESIS OF 2-SUBSTITUTED ADENOSINES | BIOVITRUM AB (SE) | 2005-06-23 | — | — | WO | disclosed |
| WO-2005054269-A1 | IMPROVED SYNTHESIS OF 2-SUBSTITUTED ADENOSINES | BIOVITRUM AB (SE) | 2005-06-16 | — | — | WO | disclosed |