Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.72 |
| ▸ | NPC1 | O15118 | 4/20 | 0.72 |
| ▸ | RAB9A | P51151 | 4/20 | 0.72 |
| ▸ | LMNA | P02545 | 2/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.58 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.55 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MMP8 | P22894 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10441979 | 1.00 | SMN1; SMN2 (0.72) | SMN1; SMN2NPC1RAB9ALMNAKDM4E | |
| SCHEMBL8062422 | 1.00 | SMN1; SMN2 (0.72) | SMN1; SMN2NPC1RAB9ALMNAKDM4E | |
| SCHEMBL11657304 | 0.87 | SMN1; SMN2 (0.59) | SMN1; SMN2NPC1RAB9ALMNAKDM4E | |
| SCHEMBL5696631 | 0.87 | NPC1 (0.55) | SMN1; SMN2NPC1RAB9ALMNAKDM4E | |
| SCHEMBL15738570 | 0.85 | SMN1; SMN2 (0.92) | SMN1; SMN2NPC1RAB9ALMNAKDM4E | |
| SCHEMBL8047567 | 0.85 | SMN1; SMN2 (0.64) | SMN1; SMN2NPC1RAB9ALMNAKDM4E | |
| SCHEMBL1950765 | 0.84 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9ALMNAKDM4E | |
| SCHEMBL8170647 | 0.84 | NPC1 (0.52) | SMN1; SMN2NPC1RAB9ALMNAKDM4E | |
| SCHEMBL28333257 | 0.84 | NPC1 (0.52) | SMN1; SMN2NPC1RAB9ALMNAKDM4E | |
| SCHEMBL25496788 | 0.83 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9ALMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697301-A2 | AMINOALCOHOL DERIVATIVES | Astellas Pharma Inc. (JP) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005061433-A2 | AMINOALCOHOL DERIVATIVES | ASTELLAS PHARMA INC. (JP) | 2005-07-07 | — | — | WO | disclosed |