SCHEMBL5706347

SCHEMBL5706347

C#Cc1cc(C#Cc2ccc(CC(=O)OCCC[SiH](C)C)c(F)c2)cc(C(=O)OC(C)C)c1

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 5/20 0.32
FFAR4 Q5NUL3 5/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4508236 0.88 FFAR1 (0.32) FFAR1FFAR4
SCHEMBL4504892 0.85 FFAR1 (0.33) FFAR1FFAR4
SCHEMBL4519235 0.83 FFAR1 (0.41) FFAR1FFAR4
SCHEMBL4504784 0.77 ACACB (0.47) FFAR1FFAR4
SCHEMBL13606699 0.74 FFAR1 (0.33) FFAR1FFAR4
SCHEMBL13613952 0.73 GLRA3 (0.34)
SCHEMBL4516332 0.72 FFAR1 (0.49) FFAR1FFAR4
SCHEMBL13606700 0.71 FFAR1 (0.41) FFAR1FFAR4
SCHEMBL4504895 0.70 ACACB (0.34)
SCHEMBL13613844 0.70 CD274 (0.38) FFAR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1696899-A1 METHODS FOR TREATING RETINOID RESPONSIVE DISORDERS USING SELECTIVE INHIBITORS OF CYP26A AND CYP26B ALLERGAN, INC. (US) 2006-09-06 EP disclosed
WO-2005058301-A1 METHODS FOR TREATING RETINOID RESPONSIVE DISORDERS USING SELECTIVE INHIBITORS OF CYP26A AND CYP26B ALLERGAN, INC. (US) 2005-06-30 WO disclosed